Biocompatible Nanoparticles for Drug-Delivery System with Field-Dependent Radical Pair System

In this paper, we used 2,2-azobis(isobutyronitrile) (AIBN) as a radical pair-forming agent to investigate whether magnetic fields can control a liposomal drug release through differences in the physical properties of biomembranes. Exposure to a static magnetic field of 0.25 T was performed using a pair of commercially available permanent magnets. Irradiations of beta-carotene-containing liposomal nanocarriers modified with AIBN were performed using an original air-cooled UV-LED irradiation system. Under exposure to the static field, the AIBN in the membrane was excited by a UV-LED emission wavelength of 365 nm. According to the overall result of seven kinds of prepared nanocarriers, the drug release potentials with magnetic field effects obtained using a static field of 0.25 T were more extensive on the order of 16-32%, than those obtained at geomagnetic fields. Conclusively, we strongly propose a novel photomagnetic controlled drug-release technology using these liposomal nanocarriers equipped with magnetic controls.