Manic episode following psilocybin use in a man with bipolar II disorder: a case report

被引:2
作者
Halim, Haniya J. [1 ]
Burk, Bradley G. [2 ]
Fargason, Rachel E. [3 ]
Birur, Badari [1 ]
机构
[1] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Dept Pharm, Birmingham, AL USA
[3] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Birmingham, AL USA
来源
FRONTIERS IN PSYCHIATRY | 2023年 / 14卷
关键词
substance-induced mania; psilocybin; bipolar disorder; magic mushrooms; psychedelic; DEPRESSION;
D O I
10.3389/fpsyt.2023.1221131
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
There has been an increase in research on the topic of psychedelic substances and their effects as treatment options in neuropsychiatric conditions. Psilocybin is a psychedelic drug that has recently garnered increased interest as an effective treatment modality for treatment-resistant depression, depression associated with terminal conditions, certain substance use disorders, and obsessive-compulsive disorder. However, sparse data exist as to the effects that psilocybin might have on patients at risk for mania, in large part secondary to the exclusion of this patient population from studies due to the concern for inducing mania or worsening illness course. We describe a case of a 21-year-old male with a recent diagnosis of bipolar II disorder who developed a manic episode following the ingestion of psilocybin in the form of hallucinogenic mushrooms. Given the incidence of depression in those with bipolar disorder, impulsivity, and a tendency to abuse substances associated with the illness, further research is needed into the risks of psilocybin and other psychedelic use in those with bipolar disorder.
引用
收藏
页数:5
相关论文
共 17 条
[1]   Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission [J].
Alex, K. D. ;
Pehek, E. A. .
PHARMACOLOGY & THERAPEUTICS, 2007, 113 (02) :296-320
[2]   Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder A Randomized Clinical Trial [J].
Bogenschutz, Michael P. ;
Ross, Stephen ;
Bhatt, Snehal ;
Baron, Tara ;
Forcehimes, Alyssa A. ;
Laska, Eugene ;
Mennenga, Sarah E. ;
O'Donnell, Kelley ;
Owens, Lindsey T. ;
Podrebarac, Samantha ;
Rotrosen, John ;
Tonigan, J. Scott ;
Worth, Lindsay .
JAMA PSYCHIATRY, 2022, 79 (10) :953-962
[3]   Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study [J].
Bogenschutz, Michael P. ;
Forcehimes, Alyssa A. ;
Pommy, Jessica A. ;
Wilcox, Claire E. ;
Barbosa, P. C. R. ;
Strassman, Rick J. .
JOURNAL OF PSYCHOPHARMACOLOGY, 2015, 29 (03) :289-299
[4]   A Physician's Attempt to Self-Medicate Bipolar Depression with N,N-Dimethyltryptamine (DMT) [J].
Brown, Tanida ;
Shao, Wanda ;
Ayub, Shehzad ;
Chong, David ;
Cornelius, Christian .
JOURNAL OF PSYCHOACTIVE DRUGS, 2017, 49 (04) :294-296
[5]   Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms [J].
Carhart-Harris, Robin L. ;
Roseman, Leor ;
Bolstridge, Mark ;
Demetriou, Lysia ;
Pannekoek, J. Nienke ;
Wall, Matthew B. ;
Tanner, Mark ;
Kaelen, Mendel ;
McGonigle, John ;
Murphy, Kevin ;
Leech, Robert ;
Curran, H. Valerie ;
Nutt, David J. .
SCIENTIFIC REPORTS, 2017, 7
[6]   D-Lysergic Acid Diethylamide (LSD) as a Model of Psychosis: Mechanism of Action and Pharmacology [J].
De Gregorio, Danilo ;
Comai, Stefano ;
Posa, Luca ;
Gobbi, Gabriella .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (11)
[7]   The Early Natural History of Bipolar Disorder: What We Have Learned From Longitudinal High-Risk Research [J].
Duffy, Anne .
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE, 2010, 55 (08) :477-485
[8]  
Gard DE., 2021, Journal of Affective Disorders Reports, V6, P100240, DOI DOI 10.1016/J.JADR.2021.100240
[9]   Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial [J].
Griffiths, Roland R. ;
Johnson, Matthew W. ;
Carducci, Michael A. ;
Umbricht, Annie ;
Richards, William A. ;
Richards, Brian D. ;
Cosimano, Mary P. ;
Klinedinst, Margaret A. .
JOURNAL OF PSYCHOPHARMACOLOGY, 2016, 30 (12) :1181-1197
[10]   An episode of mania following self-reported ingestion of psilocybin mushrooms in a woman previously not diagnosed with bipolar disorder: A case report [J].
Hendin, Holly M. ;
Penn, Andrew D. .
BIPOLAR DISORDERS, 2021, 23 (07) :733-735