iPSCs as a groundbreaking tool for the study of adverse drug reactions: A new avenue for personalized therapy

被引:4
作者
Rispoli, Paola [1 ]
Piovesan, Tatiana Scandiuzzi [1 ]
Decorti, Giuliana [1 ,2 ]
Stocco, Gabriele [1 ,2 ]
Lucafo, Marianna [3 ]
机构
[1] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy
[2] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Trieste, Italy
[3] Univ Trieste, Dept Life Sci, Trieste, Italy
来源
WIRES MECHANISMS OF DISEASE | 2024年 / 16卷 / 01期
关键词
adverse drug reactions; induced pluripotent stem cells; medicine; organoids; personalized; pharmacology; PLURIPOTENT STEM-CELLS; AZATHIOPRINE-INDUCED PANCREATITIS; ON-A-CHIP; GENERATION; MODEL; DIFFERENTIATION; ASSEMBLOIDS; MECHANISMS; BIOMARKERS; ORGANOIDS;
D O I
10.1002/wsbm.1630
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Induced pluripotent stem cells (iPSCs), obtained by reprogramming different somatic cell types, represent a promising tool for the study of drug toxicities, especially in the context of personalized medicine. Indeed, these cells retain the same genetic heritage of the donor, allowing the development of personalized models. In addition, they represent a useful tool for the study of adverse drug reactions (ADRs) in special populations, such as pediatric patients, which are often poorly represented in clinical trials due to ethical issues. Particularly, iPSCs can be differentiated into any tissue of the human body, following several protocols which use different stimuli to induce specific differentiation processes. Differentiated cells also maintain the genetic heritage of the donor, and therefore are suitable for personalized pharmacological studies; moreover, iPSC-derived differentiated cells are a valuable tool for the investigation of the mechanisms underlying the physiological differentiation processes. iPSCs-derived organoids represent another important tool for the study of ADRs. Precisely, organoids are in vitro 3D models which better represent the native organ, both from a structural and a functional point of view. Moreover, in the same way as iPSC-derived 2D models, iPSC-derived organoids are appropriate personalized models since they retain the genetic heritage of the donor. In comparison to other in vitro models, iPSC-derived organoids present advantages in terms of versatility, patient-specificity, and ethical issues. This review aims to provide an updated report of the employment of iPSCs, and 2D and 3D models derived from these, for the study of ADRs.This article is categorized under: Cancer > Stem Cells and Development
引用
收藏
页数:25
相关论文
共 50 条
[41]   Economic burden of hospital admissions for adverse drug reactions in France: The IATROSTAT-ECO study [J].
Laroche, Marie-Laure ;
Tarbouriech, Noemie ;
Jai, Taha ;
Valnet-Rabier, Marie-Blanche ;
Nerich, Virginie .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2025, 91 (02) :439-450
[42]   Adverse drug reactions associated with concurrent acute psychiatric treatment and Covid-19 drug therapy [J].
Sonmez Gungor, Ekin ;
Yalcin, Murat ;
Yerebakan Tuzer, Melike ;
Besikci Keles, Didem ;
Ocek Bas, Tuba ;
Ergelen, Mine ;
Bulbul, Alper ;
Kirsavoglu, Betul ;
Gunes, Mustafa .
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 2021, 25 (02) :142-146
[43]   Improving the assessment of adverse drug reactions using the Naranjo Algorithm in daily practice: The Japan Adverse Drug Events Study [J].
Murayama, Hiroki ;
Sakuma, Mio ;
Takahashi, Yuri ;
Morimoto, Takeshi .
PHARMACOLOGY RESEARCH & PERSPECTIVES, 2018, 6 (01)
[44]   Adverse drug reactions to self-medication: a study in a pharmacovigilance database [J].
Berreni, Aurelia ;
Montastruc, Francois ;
Bondon-Guitton, Emmanuelle ;
Rousseau, Vanessa ;
Abadie, Delphine ;
Durrieu, Genevieve ;
Chebane, Leila ;
Giroud, Jean-Paul ;
Bagheri, Haleh ;
Montastruc, Jean-Louis .
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2015, 29 (05) :517-520
[45]   A prospective study on Adverse Drug Reactions of antibiotics in a tertiary care hospital [J].
Shamna, M. ;
Dilip, C. ;
Ajmal, M. ;
Mohan, P. Linu ;
Shinu, C. ;
Jafer, C. P. ;
Mohammed, Yahiya .
SAUDI PHARMACEUTICAL JOURNAL, 2014, 22 (04) :303-308
[46]   Epidemiology of hospitalization due to adverse drug reactions in France: The IATROSTAT study [J].
Laroche, M. L. ;
Polard, E. ;
Gautier, S. ;
Lebrun-Vignes, B. ;
Faillie, J. L. ;
Chouchana, L. ;
Valnet-Rabier, M. B. ;
Massy, N. ;
Triquet, L. ;
Gras-Champel, V. ;
Mahe, J. ;
Jantzem, H. ;
Fedrizzi, S. ;
Gouraud, A. ;
Tebacher-Alt, M. ;
De Canecaude, C. .
FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2021, 35 :18-19
[47]   The evaluation of adverse drug reactions in Saudi Arabia: A retrospective observational study [J].
Alenzi, Khalidah A. ;
Alanazi, Najah S. ;
Almalki, Mohammed ;
Alomrani, Homoud ;
Alatawi, Fahad O. .
SAUDI PHARMACEUTICAL JOURNAL, 2022, 30 (06) :735-741
[48]   Adverse Drug Reactions in Hospitalized Pediatric Patients: A Prospective Observational Study [J].
J. Kurian ;
J. Mathew ;
K. Sowjanya ;
K. R. K. Chaitanya ;
M. Ramesh ;
J. Sebastian ;
D. Narayanappa .
The Indian Journal of Pediatrics, 2016, 83 :414-419
[49]   Adverse Drug Reactions in Hospitalized Pediatric Patients: A Prospective Observational Study [J].
Kurian, J. ;
Mathew, J. ;
Sowjanya, K. ;
Chaitanya, K. R. K. ;
Ramesh, M. ;
Sebastian, J. ;
Narayanappa, D. .
INDIAN JOURNAL OF PEDIATRICS, 2016, 83 (05) :414-419
[50]   Adverse drug reactions causing admission to a paediatric hospital: a pilot study [J].
Gallagher, R. M. ;
Bird, K. A. ;
Mason, J. R. ;
Peak, M. ;
Williamson, P. R. ;
Nunn, A. J. ;
Turner, M. A. ;
Pirmohamed, M. ;
Smyth, R. L. .
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2011, 36 (02) :194-199