Combination of interferons in patients with high-grade brain tumors without therapeutic options

被引:0
作者
Margarita Rios-Cabrera, Maria [1 ]
Bello-Rivero, Iraldo [2 ]
Cruz-Rodriguez, Javier [3 ]
机构
[1] Hosp Prov Clin Quirurg Arnaldo Milian Castro, Dept Invest, Santa Clara, CA, Cuba
[2] Ctr Ingn Genet & Biotecnol, Dept Invest Clin, Havana, Cuba
[3] Hosp Prov Clin Quirurg Arnaldo Milian Castro, Serv Cirugia Gen, Santa Clara, CA, Cuba
关键词
brain tumor; interferon; clinical research; PHASE-I; GLIOBLASTOMA;
D O I
10.30827/ars.v64i4.27824
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Introduction: The poor survival of patients with high-grade malignancy brain tumors, despite the existence of some treatment options, leads to the search for new therapeutic modalities. The cuban combination of alpha and gamma interferons is novel and there is evidence that it increases the survival of patients with solid tumors. Method: A clinical investigation was conducted to determine the efficiency of the combination in patients with high-grade brain tumors without therapeutic options. 40 patients treated at the "Arnaldo Milian Castro" Hospital in the period 2009-2020 were included, safety and efficacy were evaluated. Results: No serious adverse events occurred, events were mild or moderate, expected, and patients recovered. After one year, 8.7 % of the cases in the experimental group had died, compared to 70.6 % in the control group. Overall survival in stage III was similar in both scenarios and in stage IV it was higher for the experimental group. The chance of survival for the patients who were treated with the combination of interferons was 0.887 times higher than the control cases. There were significant differences in functional capacity between both groups of patients. Conclusions: It was evidenced that the Cuban combination of interferons is safe and effective for the treatment of high-grade malignancy brain tumors without therapeutic options, which makes it an efficient option in this clinical scenario.
引用
收藏
页码:315 / 328
页数:14
相关论文
共 50 条
[41]   Caring for Patients with Newly Diagnosed High-Grade Gliomas [J].
Grossman, Stuart A. ;
Piotrowski, Anna F. .
SEMINARS IN NEUROLOGY, 2016, 36 (04) :324-329
[42]   High-grade glioma: elderly patients, older treatments [J].
De Bonis, Pasquale ;
Mangiola, Annunziato ;
Pompucci, Angelo ;
Porso, Manuela ;
Anile, Carmelo .
EXPERT REVIEW OF NEUROTHERAPEUTICS, 2012, 12 (11) :1293-1296
[43]   Mapping genetic factors in high-grade glioma patients [J].
Yang Yuan ;
Mao Yunhe ;
Wang Xiang ;
Liu Yanhui ;
Liang Ruofei ;
Luo Jiewen ;
Mao Qing .
CLINICAL NEUROLOGY AND NEUROSURGERY, 2016, 150 :159-163
[44]   Carboplatin Chemotherapy in Patients with Recurrent High-grade Glioma [J].
Murray, L. J. ;
Bridgewater, C. H. ;
Levy, D. .
CLINICAL ONCOLOGY, 2011, 23 (01) :55-61
[45]   CD200AR-L: mechanism of action and preclinical and clinical insights for treating high-grade brain tumors [J].
Moertel, Christopher ;
Martinez-Puerta, Francisco ;
Pluhar, Grace G. Elizabeth ;
Castro, Maria Graciela ;
Olin, Michael .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2022, 31 (09) :875-879
[46]   Phase I Study of Vorinostat in Combination with Temozolomide in Patients with High-Grade Gliomas: North American Brain Tumor Consortium Study 04-03 [J].
Lee, Eudocia Q. ;
Puduvalli, Vinay K. ;
Reid, Joel M. ;
Kuhn, John G. ;
Lamborn, Kathleen R. ;
Cloughesy, Timothy F. ;
Chang, Susan M. ;
Drappatz, Jan ;
Yung, W. K. Alfred ;
Gilbert, Mark R. ;
Robins, H. Ian ;
Lieberman, Frank S. ;
Lassman, Andrew B. ;
McGovern, Renee M. ;
Xu, Jihong ;
Desideri, Serena ;
Ye, Xiabu ;
Ames, Matthew M. ;
Espinoza-Delgado, Igor ;
Prados, Michael D. ;
Wen, Patrick Y. .
CLINICAL CANCER RESEARCH, 2012, 18 (21) :6032-6039
[47]   Case Report: Brain tumor's pitfalls: two cases of high-grade brain tumors mimicking autoimmune encephalitis with positive onconeuronal antibodies [J].
Consoli, Stefano ;
Dono, Fedele ;
Evangelista, Giacomo ;
Corniello, Clarissa ;
Onofrj, Marco ;
Thomas, Astrid ;
Sensi, Stefano L. .
FRONTIERS IN ONCOLOGY, 2023, 13
[48]   Phase I study of panobinostat in combination with bevacizumab for recurrent high-grade glioma [J].
Drappatz, J. ;
Lee, E. Q. ;
Hammond, S. ;
Grimm, S. A. ;
Norden, A. D. ;
Beroukhim, R. ;
Gerard, M. ;
Schiff, D. ;
Chi, A. S. ;
Batchelor, T. T. ;
Doherty, L. M. ;
Ciampa, A. S. ;
LaFrankie, D. C. ;
Ruland, S. ;
Snodgrass, S. M. ;
Raizer, J. J. ;
Wen, P. Y. .
JOURNAL OF NEURO-ONCOLOGY, 2012, 107 (01) :133-138
[49]   Anlotinib as Monotherapy or Combination Therapy for Recurrent High-Grade Glioma: A Retrospective Study [J].
Yin, Jun ;
Yin, Wenya ;
Zheng, Linlin ;
Li, Yimin ;
Luo, Cheng ;
Zhang, Shuo ;
Duan, Lei ;
Zhou, Hang ;
Cheng, Kai ;
Lang, Jinyi ;
Xu, Ke .
CLINICAL MEDICINE INSIGHTS-ONCOLOGY, 2023, 17
[50]   Re-irradiation with stereotactic radiotherapy for recurrent high-grade glial tumors [J].
Soykut, Ela Delikgoz ;
Odabasi, Eylem ;
Sahin, Nilgun ;
Tataroglu, Hatice ;
Baran, Ahmet ;
Guney, Yildiz .
REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY, 2023, 28 (03) :361-369