Recent Advancements in Gremlin-1: Breast cancer

被引：1
作者：
Inam, Nimrah [1 ]
Hameed, Ayesha [2 ]
Vohra, Lubna [3 ]
Zeeshan, Sana [3 ]
机构：
[1] Aga Khan Univ Hosp, Dept Paediat, Karachi, Pakistan
[2] Jinnah Med & Dent Coll, Karachi, Pakistan
[3] Aga Khan Univ Hosp, Dept Breast Surg, Karachi, Pakistan
来源：
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION | 2023年 / 73卷 / 02期
关键词：
Bone Morphogenetic; Carcinogenesis; Organogenesis; Colorectal Neoplasms; breast cancers; stem cells; TARGETED THERAPIES; CELLS; METASTASIS; GROWTH;
D O I：
10.47391/JPMA.AKUS-25
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
One of the bone's morphogenic protein (BMP) antagonists, Gremlin-1 or GREM-1, can bind directly to BMPs. GREM-1 can act in either BMP-dependent or independent pathways, according to research. It reinforces organogenesis, tissue differentiation, and organ fibrosis. Recent research from numerous studies has demonstrated the significance of GREM-1 in the initiation, progression, and even metastasis of different cancers, including breast, cervical, gastric, and colorectal cancers. This review highlights the function of GREM-1 in the development of breast cancer and its effect on the cellular procedures and signalling pathways involved in carcinogenesis.
引用
收藏
页码：S155 / S159
页数：5
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