From molecular basis to clinical insights: a challenging future for the vitamin D endocrine system in colorectal cancer

被引：4

作者：

Pereira, Fabio ^{[1
,2
]}

Fernandez-Barral, Asuncion ^{[1
,3
,4
]}

Larriba, Maria Jesus ^{[1
,3
,4
]}

Barbachano, Antonio ^{[1
,3
,4
,6
]}

Gonzalez-Sancho, Jose Manuel ^{[1
,3
,4
,5
,6
]}

机构：

[1] Univ Autonoma Madrid, CSIC, Inst Invest Biomed Sols Morreale, Madrid, Spain

[2] Complejo Hosp Univ Ourense, Serv Oncol Radioterap, Orense, Spain

[3] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain

[4] Univ Autonoma Madrid, Inst Invest Sanitaria Hosp Univ La Paz IdiPAZ, Hosp Univ La Paz, Madrid, Spain

[5] Univ Autonoma Madrid, Fac Med, Dept Bioquim, Madrid, Spain

[6] Inst Invest Biomed Sols Morreale, Calle Arturo Duperier 4, Madrid 28029, Spain

来源：

FEBS JOURNAL | 2024年 / 291卷 / 12期

关键词：

colorectal cancer; epidemiology; mechanisms of action; randomized controlled trials; vitamin D; HUMAN-COLON-CANCER; D-RECEPTOR GENE; NF-KAPPA-B; EPIDERMAL-GROWTH-FACTOR; ANTAGONIST DICKKOPF-1 GENE; WNT/BETA-CATENIN PATHWAY; CARCINOMA CELL-LINE; D SUPPLEMENTATION; D METABOLISM; 1,25-DIHYDROXYVITAMIN D-3;

D O I：

10.1111/febs.16955

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer (CRC) is one of the most life-threatening neoplasias in terms of incidence and mortality worldwide. Vitamin D deficiency has been associated with an increased risk of CRC. 1 & alpha;,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the most active vitamin D metabolite, is a pleiotropic hormone that, through its binding to a transcription factor of the nuclear receptor superfamily, is a major regulator of the human genome. 1,25(OH)2D3 acts on colon carcinoma and stromal cells and displays tumor protective actions. Here, we review the variety of molecular mechanisms underlying the effects of 1,25(OH)2D3 in CRC, which affect multiple processes that are dysregulated during tumor initiation and progression. Additionally, we discuss the epidemiological data that associate vitamin D deficiency and CRC, and the most relevant randomized controlled trials of vitamin D3 supplementation conducted in both healthy individuals and CRC patients. Here, we review the variety of molecular mechanisms underlying the antitumor effects of the vitamin D endocrine system in colorectal cancer (CRC), which affect multiple processes that are dysregulated during tumor initiation and progression. Additionally, we discuss the epidemiological data that associate vitamin D deficiency and CRC, and the most relevant randomized controlled trials of vitamin D3 supplementation conducted in both healthy individuals and CRC patients.image

引用

页码：2485 / 2518

页数：34