Review of the Application of Raman Spectroscopy in Qualitative and Quantitative Analysis of Drug Polymorphism

被引：5

作者：

Sun, Zhongyu ^{[1
]}

Lin, Boran ^{[1
]}

Yang, Xiangchun ^{[1
]}

Zhao, Bing ^{[1
]}

Zhang, Hui ^{[1
]}

Dong, Qin ^{[1
]}

Zhong, Liang ^{[1
]}

Zhang, Shuaihua ^{[1
]}

Zhang, Mengqi ^{[1
]}

Xu, Xiuhua ^{[1
]}

Dong, Hailing ^{[1
]}

Li, Haoyuan ^{[1
]}

Li, Lian ^{[1
,2
]}

Nie, Lei ^{[1
]}

Zang, Hengchang ^{[1
,2
,3
]}

机构：

[1] Shandong Univ, Inst Biochem & Biotechnol Drug, Cheeloo Coll Med, Sch Pharmaceut Sci,NMPA Key Lab Technol Res & Eval, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Key Lab Chem Biol, Minist Educ, Jinan 250012, Shandong, Peoples R China

[3] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250012, Shandong, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2023年 / 23卷 / 14期

关键词：

Drug polymorphism; Raman spectroscopy; Quantitative analysis; Qualitative analysis; Active pharmaceutical ingredient; Bioavailability; SOLID-STATE CHARACTERIZATION; RAY-POWDER DIFFRACTION; VIBRATIONAL SPECTROSCOPY; PHASE-TRANSFORMATION; CRYSTAL POLYMORPHISM; MEFENAMIC-ACID; MIXTURES; HYDROCHLORIDE; STABILITY; FORMS;

D O I：

10.2174/1568026623666221223113342

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Drug polymorphism is an important factor affecting the drugs quality and clinical efficacy. Therefore, great attention should be paid to the crystal analysis of drugs with their researching and evaluating part. With the booming development of Raman spectroscopy in recent years, more and more crystal analysis investigations were based on vibrational spectroscopy. This review mainly discussed the qualitative and quantitative analysis of active pharmaceutical ingredients (API) and pharmaceutical preparation with Raman spectroscopy. On basis of the determination of the vibration mode of drug molecules and the analysis of their chemical structure, this method had the advantages of universal, non-destructive, fast determination, low samples and cost, etc. This review provides theoretical and technical support for crystal structure, which are worth popularizing. It is expected that it will be helpful to relevant government management institutions, pharmaceutical scientific research institutions and pharmaceutical manufacturers.

引用

页码：1340 / 1351

页数：12

共 102 条

[11] Mefenamic Acid Anti-Inflammatory Drug: Probing Its Polymorphs by Vibrational (IR and Raman) and Solid-State NMR Spectroscopies
Cunha, Vanessa R. R.
Izumi, Celly M. S.
Petersen, Philippe A. D.
Magalhaes, Alvicler
Temperini, Marcia L. A.
Petrilli, Helena M.
Constantino, Vera R. L.
[J]. JOURNAL OF PHYSICAL CHEMISTRY B, 2014, 118 (16) : 4333 - 4344
[12] Raman spectroscopy: Recent advancements, techniques and applications
Das, Ruchita S.
Agrawal, Y. K.
[J]. VIBRATIONAL SPECTROSCOPY, 2011, 57 (02) : 163 - 176
[13] Polymorphic forms of bisoprolol fumarate
Detrich, Adam
Domotor, Kata Judit
Katona, Miklos Tamas
Markovits, Imre
Lang, Judit Vargane
[J]. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2019, 135 (06) : 3043 - 3055
[14] Investigation of Polymorphism and Cocrystallization of Active Pharmaceutical Ingredients Using Vibrational Spectroscopic Techniques
Du, Yong
Xue, Jiadan
[J]. CURRENT PHARMACEUTICAL DESIGN, 2016, 22 (32) : 4917 - 4928
[15] Chemometric quantitation of the active substance (containing CN) in a pharmaceutical tablet using near-infrared (NIR) transmittance and NIR FT-Raman spectra
Dyrby, M
Engelsen, SB
Norgaard, L
Bruhn, M
Lundsberg-Nielsen, L
[J]. APPLIED SPECTROSCOPY, 2002, 56 (05) : 579 - 585
[16] Transmission Electron Microscopy of Pharmaceutical Materials
Eddleston, Mark D.
Bithell, Erica G.
Jones, William
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2010, 99 (09) : 4072 - 4083
[17] Characterization of New Cocrystals by Raman Spectroscopy, Powder X-ray Diffraction, Differential Scanning Calorimetry, and Transmission Raman Spectroscopy
Elbagerma, M. A.
Edwards, H. G. M.
Munshi, T.
Hargreaves, M. D.
Matousek, Pavel
Scowen, I. J.
[J]. CRYSTAL GROWTH & DESIGN, 2010, 10 (05) : 2360 - 2371
[18] Application of Vibrational Spectroscopy to Study Solid- state Transformations of Pharmaceuticals
Erxleben, Andrea
[J]. CURRENT PHARMACEUTICAL DESIGN, 2016, 22 (32) : 4883 - 4911
[19] Recent advances in the applications of vibrational spectroscopic imaging and mapping to pharmaceutical formulations
Ewing, Andrew V.
Kazarian, Sergei G.
[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2018, 197 : 10 - 29
[20] Investigation of the Sensitivity of Transmission Raman Spectroscopy for Polymorph Detection in Pharmaceutical Tablets
Feng, Hanzhou
Bondi, Robert W., Jr.
Anderson, Carl A.
Drennen, James K., III
Igne, Benoit
[J]. APPLIED SPECTROSCOPY, 2017, 71 (08) : 1856 - 1867

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