Review of the Application of Raman Spectroscopy in Qualitative and Quantitative Analysis of Drug Polymorphism

被引：5

作者：

Sun, Zhongyu ^{[1
]}

Lin, Boran ^{[1
]}

Yang, Xiangchun ^{[1
]}

Zhao, Bing ^{[1
]}

Zhang, Hui ^{[1
]}

Dong, Qin ^{[1
]}

Zhong, Liang ^{[1
]}

Zhang, Shuaihua ^{[1
]}

Zhang, Mengqi ^{[1
]}

Xu, Xiuhua ^{[1
]}

Dong, Hailing ^{[1
]}

Li, Haoyuan ^{[1
]}

Li, Lian ^{[1
,2
]}

Nie, Lei ^{[1
]}

Zang, Hengchang ^{[1
,2
,3
]}

机构：

[1] Shandong Univ, Inst Biochem & Biotechnol Drug, Cheeloo Coll Med, Sch Pharmaceut Sci,NMPA Key Lab Technol Res & Eval, Jinan 250012, Shandong, Peoples R China

[2] Shandong Univ, Key Lab Chem Biol, Minist Educ, Jinan 250012, Shandong, Peoples R China

[3] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250012, Shandong, Peoples R China

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2023年 / 23卷 / 14期

关键词：

Drug polymorphism; Raman spectroscopy; Quantitative analysis; Qualitative analysis; Active pharmaceutical ingredient; Bioavailability; SOLID-STATE CHARACTERIZATION; RAY-POWDER DIFFRACTION; VIBRATIONAL SPECTROSCOPY; PHASE-TRANSFORMATION; CRYSTAL POLYMORPHISM; MEFENAMIC-ACID; MIXTURES; HYDROCHLORIDE; STABILITY; FORMS;

D O I：

10.2174/1568026623666221223113342

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Drug polymorphism is an important factor affecting the drugs quality and clinical efficacy. Therefore, great attention should be paid to the crystal analysis of drugs with their researching and evaluating part. With the booming development of Raman spectroscopy in recent years, more and more crystal analysis investigations were based on vibrational spectroscopy. This review mainly discussed the qualitative and quantitative analysis of active pharmaceutical ingredients (API) and pharmaceutical preparation with Raman spectroscopy. On basis of the determination of the vibration mode of drug molecules and the analysis of their chemical structure, this method had the advantages of universal, non-destructive, fast determination, low samples and cost, etc. This review provides theoretical and technical support for crystal structure, which are worth popularizing. It is expected that it will be helpful to relevant government management institutions, pharmaceutical scientific research institutions and pharmaceutical manufacturers.

引用

页码：1340 / 1351

页数：12

共 102 条

[1] Transmission Raman spectroscopy as a tool for quantifying polymorphic content of pharmaceutical formulations
Aina, Adeyinka
Hargreaves, Michael D.
Matousek, Pavel
Burley, Jonathan C.
[J]. ANALYST, 2010, 135 (09) : 2328 - 2333
[2] Conformational Polymorphs of a Muscle Relaxant, Metaxalone
Aitipamula, Srinivasulu
Chow, Pui Shan
Tan, Reginald B. H.
[J]. CRYSTAL GROWTH & DESIGN, 2011, 11 (09) : 4101 - 4109
[3] Rapid polymorph screening on milligram quantities of pharmaceutical material using phonon-mode Raman spectroscopy
Al-Dulaimi, Sarah
Aina, Adeyinka
Burley, Jonathan
[J]. CRYSTENGCOMM, 2010, 12 (04): : 1038 - 1040
[4] Solid state characterization of olanzapine polymorphs using vibrational spectroscopy
Ayala, A. P.
Siesler, H. W.
Boese, R.
Hoffmann, G. G.
Polla, G. I.
Vega, D. R.
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2006, 326 (1-2) : 69 - 79
[5] Phase transitions in secnidazole: Thermal stability and polymorphism studied by X-ray powder diffraction, thermal analysis and vibrational spectroscopy
Bezerra, Beatriz Pinheiro
Fonseca, Jessica Castro
de Oliveira, Yara Santiago
de Santana, Maria Silmara A.
Silva, Keilla F.
Araujo, Bruno S.
Ayala, Alejandro Pedro
[J]. VIBRATIONAL SPECTROSCOPY, 2016, 86 : 90 - 96
[6] Detection of low dose of piroxicam polymorph in pharmaceutical tablets by surface-enhanced Raman chemical imaging (SER-CI) and multivariate analysis
Cailletaud, Johan
De Bleye, Charlotte
Dumont, Elodie
Sacre, Pierre-Yves
Gut, Yoann
Leblanc, Nicolas
Letellier, Philippe
Ginot, Yves-Michel
Hubert, Philippe
Ziemons, Eric
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020, 574
[7] Raman microspectroscopic mapping or thermal system used to investigate milling-induced solid-state conversion of famotidine polymorphs
Cheng, Wen-Ting
Lin, Shan-Yang
Li, Mei-Jane
[J]. JOURNAL OF RAMAN SPECTROSCOPY, 2007, 38 (12) : 1595 - 1601
[8] Eutectics as improved pharmaceutical materials: design, properties and characterization
Cherukuvada, Suryanarayan
Nangia, Ashwini
[J]. CHEMICAL COMMUNICATIONS, 2014, 50 (08) : 906 - 923
[9] Enhancement of the dissolution rate and gastrointestinal absorption of pranlukast as a model poorly water-soluble drug by grinding with gelatin
Chono, Sumio
Takeda, Eri
Seki, Toshinobu
Morimoto, Kazuhiro
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 347 (1-2) : 71 - 78
[10] Comparison of near-infrared, infrared, and Raman spectroscopy for the analysis of heavy petroleum products
Chung, H
Ku, MS
[J]. APPLIED SPECTROSCOPY, 2000, 54 (02) : 239 - 245

← 1 2 3 4 5 6 7 8 9 10 →