Discovery and development of a potent and highly selective WEE1 inhibitor IMP7068

被引:2
|
作者
Cai, Sui Xiong
Ma, Ning
Wang, Xiaozhu
Jiang, Yangzhen
Zhang, Hongxia
Guo, Mingchuan
Zhou, Ruiyu
Tian, Ye Edward
机构
关键词
D O I
10.1158/1538-7445.AM2023-3091
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3091
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery
    Erlanson, Daniel A.
    Arndt, Joseph W.
    Cancilla, Mark T.
    Cao, Kathy
    Elling, Robert A.
    English, Nicki
    Friedman, Jessica
    Hansen, Stig K.
    Hession, Cathy
    Joseph, Ingrid
    Kumaravel, Gnanasambandam
    Lee, Wen-Cherng
    Lind, Ken E.
    McDowell, Robert S.
    Miatkowski, Konrad
    Nguyen, Christine
    Nguyen, Thinh B.
    Park, Sophia
    Pathan, Nuzhat
    Penny, David M.
    Romanowski, Michael J.
    Scott, Daniel
    Silvian, Laura
    Simmons, Robert L.
    Tangonan, Bradley T.
    Yang, Wenjin
    Sun, Lihong
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (10) : 3078 - 3083
  • [22] Discovery and development of Santacruzamate A, a potent and selective histone deacetylase inhibitor
    Balunas, M. J.
    Pavlik, C. M.
    Wong, C. Y. B.
    Lopez, D. D.
    Engene, N.
    McPhail, K.
    Gerwick, W. H.
    PLANTA MEDICA, 2012, 78 (11) : 1050 - 1050
  • [23] Cdk1-dependent regulation of the mitotic inhibitor Wee1
    Harvey, SL
    Charlet, A
    Haas, W
    Gygi, SP
    Kellogg, DR
    CELL, 2005, 122 (03) : 407 - 420
  • [24] Antitumor effect of Wee1 inhibitor in gastric cancer cells
    Kim, Seongyeong
    Min, Ahrum
    Kim, So Hyeon
    Ha, Dong Hyeon
    Jang, Hyemin
    Kim, Yu Jin
    Kim, Hee Jun
    Lee, Kyung-Hun
    Kim, Tae-Yong
    Oh, Do-Youn
    Bang, Yung-Jue
    Im, Seock-Ah
    CANCER RESEARCH, 2017, 77
  • [25] Discovery of a highly potent and selective PARP1 inhibitor with superior PK and safety profiles
    Wei, Yi
    Li, Wenming
    Li, Zehui
    Li, Manhua
    Kang, Kai
    Wen, Zhiming
    Yin, Tinggui
    Yu, Kuo-Long
    Zhao, Genshi
    Yuan, Hongbin
    CANCER RESEARCH, 2024, 84 (06)
  • [26] Discovery of a Highly Potent and Selective Indenoindolone Type 1 Pan-FLT3 Inhibitor
    Hatcher, John M.
    Weisberg, Ellen
    Sim, Taebo
    Stone, Richard M.
    Liu, Suiyang
    Griffin, James D.
    Gray, Nathanael S.
    ACS MEDICINAL CHEMISTRY LETTERS, 2016, 7 (05): : 476 - 481
  • [27] Investigation of antitumor effect of Wee1 inhibitor on colorectal cancer
    Ariyoshi, Misa
    Yuge, Ryo
    Shimizu, Daisuke
    Miyamoto, Ryo
    Otani, Rina
    Takigawa, Hidehiko
    Urabe, Yuji
    Oka, Shiro
    CANCER SCIENCE, 2024, 115 : 531 - 531
  • [28] The discovery and development of Lindorestat, a highly potent and selective inhibitor of aldose reductase for treatment of diabetic complications.
    Van Zandt, MC
    Jones, JH
    Geraci, LS
    Gunn, DE
    Jones, ML
    Sawicki, D
    Sredy, J
    Howard, E
    Podjarny, A
    Cannan, S
    Carrington, A
    Sabetta, A
    Jacot, J
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : A91 - A91
  • [29] Discovery of potent, selective, and orally available WEE1 inhibitors that demonstrate increased DNA damage and mitosis in tumor cells leading to tumor regression in vivo
    Sun, Shaoxian
    Silvergleid, Sarah
    Gerasyuto, Aleksey I.
    Wang, Jiashi
    Pelletier, Robert D.
    Placzek, Andrew
    Knight, Jennifer L.
    Clark, Anthony
    Wright, Hamish
    Yin, Wu
    Elk, Jackson Chief
    Bell, Jeff
    Bos, Pieter H.
    Boyles, Nicholas A.
    Therrien, Eric
    Jensen, Kristian
    Akinsanya, Karen
    CANCER RESEARCH, 2022, 82 (12)
  • [30] Activity of MK1775, a selective Wee1 inhibitor, alone or in combination with gemcitabine, in sarcomas.
    Kreahling, Jenny
    Reed, Damon R.
    Foroutan, Parastou
    Martinez, Gary
    Gillies, Robert
    Altiok, Soner
    JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)