Thermoregulatory responses, heart rate, and the susceptibility to anxiety in obese animals subjected to stress

被引:1
|
作者
Santos, Aquila Rodrigues Costa [1 ,2 ]
Abreu, Aline Rezende R. [3 ]
Noronha, Sylvana I. S. R. [3 ]
Reis, Thayane Oliveira [3 ]
Santos, Daisy Motta [4 ]
Chianca-JR, Deoclecio Alves [3 ]
da Silva, Luiz Gonzaga [2 ]
de Menezes, Rodrigo Cunha Alvim [3 ]
Velloso-Rodrigues, Cibele [2 ,5 ]
机构
[1] Fundacao Oswaldo Cruz, Oswaldo Cruz Inst, Lab Thymus Res, Rio De Janeiro, Brazil
[2] Univ Fed Juiz de Fora, Dept Basic Life Sci, Governador Valadares, Brazil
[3] Univ Fed Ouro Preto, Dept Biol Sci, Lab Cardiovasc Physiol, Ouro Preto, Brazil
[4] Univ Fed Minas Gerais, Sch Phys Educ Physiotherapy & Occupat Therapy, Dept Sports, Belo Horizonte, Brazil
[5] Univ Fed Juiz de Fora, Dept Basic Life Sci, Lab Cell Biol & Mol Genet, BR-35032200 Governador Valadares, MG, Brazil
关键词
Obesity; Stress; Thermoregulatory responses; Heart rate; Anxiety -like behavior; Behavior; ADIPOSE-TISSUE THERMOGENESIS; SYMPATHETIC-NERVE ACTIVITY; FAT DIET ALTERS; DORSOMEDIAL HYPOTHALAMUS; PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; VISCERAL FAT; RISK-FACTOR; BEHAVIOR; INFLAMMATION;
D O I
10.1016/j.physbeh.2023.114181
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Obesity and stress are related to cardiovascular diseases. Rats fed a high-fat diet (HFD) show increased cardiovascular reactivity to emotional stress and altered defensive behavioral responses. Indeed, changes in thermoregulatory responses in an aversive environment are observed in these animals. However, studies aimed at clarifying the physiological mechanisms linking obesity, stress hyperreactivity and behavioral changes are needed. The aim of this study was to evaluate the changes in thermoregulatory responses, heart rate, and the susceptibility to anxiety in obese animals subjected to stress. Nine-week high-fat diet protocol was effective in inducing obesity by increasing weight gain, fat mass, adiposity index, white epididymal, retroperitoneal, inguinal and brown adipose tissue. Animals induced to obesity and subjected to stress (HFDS group) by the intruder animal method showed increases in heart rate (HR), core body temperature and tail temperature. HFDS showed an increase in the first exposure to the closed arm (anxiety-like behavior) in elevated T-Maze (ETM). The groups did not differ with respect to panic behavior assessed in the ETM and locomotor activity in the open field test. Our study shows that HFDS animals presented increased reactivity to stress with higher stress hyperthermia and anxious behavior. Thus, our results present relevant information regarding stress responsiveness and behavioral changes in obese animals.
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收藏
页数:9
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