Inheritance of epigenetic DNA marks studied in new mouse model

被引：3

作者：

McGraw, Serge ^{[1
,2
]}

Kimmins, Sarah ^{[3
,4
]}

机构：

[1] Univ Montreal, Fac Med, Dept Obstet & Gynecol, Quebec City, PQ H3C 3J7, Canada

[2] CHU Sainte Justine Res Ctr, Montreal, PQ, Canada

[3] Univ Montreal, Fac Med, Dept Pathol & Cell Biol, Quebec City, PQ H3C 3J7, Canada

[4] CHUM Res Ctr, Montreal, PQ, Canada

来源：

NATURE | 2023年 / 615卷 / 7954期

关键词：

Epigenetics; METHYLATION;

D O I：

10.1038/d41586-023-00708-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There is debate about how epigenetic marks, such as methyl groups on DNA, can be passed down from parent to offspring. A mouse model involving targeted DNA methylation will better equip researchers to study this process.

引用

页码：800 / 802

页数：3

共 10 条

[1] Advances in epigenetics link genetics to the environment and disease [J].

Cavalli, Giacomo ;

Heard, Edith .

NATURE, 2019, 571 (7766) :489-499

[2] Molecular mechanisms of transgenerational epigenetic inheritance [J].

Fitz-James, Maximilian H. ;

Cavalli, Giacomo .

NATURE REVIEWS GENETICS, 2022, 23 (06) :325-341

[3] Roles of transposable elements in the regulation of mammalian transcription [J].

Fueyo, Raquel ;

Judd, Julius ;

Feschotte, Cedric ;

Wysocka, Joanna .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2022, 23 (07) :481-497

[4] A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C-elegans [J].

Greer, Eric L. ;

Beese-Sims, Sara E. ;

Brookes, Emily ;

Spadafora, Ruggero ;

Zhu, Yun ;

Rothbart, Scott B. ;

Aristizabal-Corrales, David ;

Chen, Shuzhen ;

Badeaux, Aimee I. ;

Jin, Qiuye ;

Wang, Wei ;

Strahl, Brian D. ;

Colaiacovo, Monica P. ;

Shi, Yang .

CELL REPORTS, 2014, 7 (01) :113-126

[5] Epigenetic inheritance at the agouti locus in the mouse [J].

Morgan, HD ;

Sutherland, HGE ;

Martin, DIK ;

Whitelaw, E .

NATURE GENETICS, 1999, 23 (03) :314-318

[6] Transgenerational inheritance of epigenetic states at the murine AxinFu allele occurs after maternal and paternal transmission [J].

Rakyan, VK ;

Chong, S ;

Champ, ME ;

Cuthbert, PC ;

Morgan, HD ;

Luu, KVK ;

Whitelaw, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2538-2543

[7] Disruption of histone methylation in developing sperm impairs offspring health transgenerationally [J].

Siklenka, Keith ;

Erkek, Serap ;

Godmann, Maren ;

Lambrot, Romain ;

McGraw, Serge ;

Lafleur, Christine ;

Cohen, Tamara ;

Xia, Jianguo ;

Suderman, Matthew ;

Hallett, Michael ;

Trasler, Jacquetta ;

Peters, Antoine H. F. M. ;

Kimmins, Sarah .

SCIENCE, 2015, 350 (6261)

[8] Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice [J].

Takahashi, Yuta ;

Valencia, Mariana Morales ;

Yu, Yang ;

Ouchi, Yasuo ;

Takahashi, Kazuki ;

Shokhirev, Maxim Nikolaievich ;

Lande, Kathryn ;

Williams, April E. ;

Fresia, Chiara ;

Kurita, Masakazu ;

Hishida, Tomoaki ;

Shojima, Kensaku ;

Hatanaka, Fumiyuki ;

Nunez-Delicado, Estrella ;

Esteban, Concepcion Rodriguez ;

Belmonte, Juan Carlos Izpisua .

CELL, 2023, 186 (04) :715-+

[9] Integration of CpG-free DNA induces de novo methylation of CpG islands in pluripotent stem cells [J].

Takahashi, Yuta ;

Wu, Jun ;

Suzuki, Keiichiro ;

Martinez-Redondo, Paloma ;

Li, Mo ;

Liao, Hsin-Kai ;

Wu, Min-Zu ;

Hernandez-Benitez, Reyna ;

Hishida, Tomoaki ;

Shokhirev, Maxim Nikolaievich ;

Esteban, Concepcion Rodriguez ;

Sancho-Martinez, Ignacio ;

Belmonte, Juan Carlos Izpisua .

SCIENCE, 2017, 356 (6337) :503-+

[10] Specification and epigenetic programming of the human germ line [J].

Tang, Walfred W. C. ;

Kobayashi, Toshihiro ;

Irie, Naoko ;

Dietmann, Sabine ;

Surani, M. Azim .

NATURE REVIEWS GENETICS, 2016, 17 (10) :585-600

← 1 →