Comparison of Insulin-Treated Patients with Ambiguous Diabetes Type with Definite Type 1 and Type 2 Diabetes Mellitus Subjects: A Clinical Perspective

被引：1

作者：

Laspe, Insa

Meier, Juris J. ^{[1
,2
,3
]}

Nauck, Michael A. ^{[1
,2
,4
]}

机构：

[1] Diabet Ctr Bad Lauterberg, Bad Lauterberg im Harz, Germany

[2] Ruhr Univ Bochum, St Josef Hosp, Katholisches Klinikum Bochum gGmbH, Dept Med 1,Diabetes,Endocrinol & Metab Sect, Bochum, Germany

[3] Augusta Hosp, Dept Internal Med, Bochum, Germany

[4] Ruhr Univ Bochum, St Josef Hosp, Katholisches Klinikum Bochum gGmbH, Dept Med 1,Endocrinol & Metab Sect, Gudrunstr 56, D-44791 Bochum, Germany

来源：

DIABETES & METABOLISM JOURNAL | 2023年 / 47卷 / 01期

关键词：

C-peptide; Diabetes mellitus; type; 1; 2; Diagnosis; differential; Insulin resistance; Latent auto-immune diabetes in adults; RESISTANCE;

D O I：

10.4093/dmj.2021.0322

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In clinical practice, the distinction between type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) can be challenging, leaving patients with "ambiguous" diabetes type. Insulin-treated patients (n=115) previously diagnosed with T2DM had to be re-classified based on clinical phenotype and laboratory results, and were operationally defined as having an ambiguous diabetes type. They were compared against patients with definite T1DM and T2DM regarding 12 clinical and laboratory features typically different between diabetes types. Characteristics of patients with ambiguous diabetes type, representing approximately 6% of all patients with T1DM or T2DM seen at our specialized clinic, fell in between those of patients with definite T1DM and T2DM, both regarding individual features and with respect to a novel classification based on multi-variable regression analysis (P< 0.0001). In conclusion, a substantial proportion of diabetes patients in a tertiary care centre presented with an "ambiguous" diabetes type. Their clinical characteristics fall in between those of definite T1DM or T2DM patients.

引用

页码：140 / 146

页数：7

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