The B(C6F5)3•H2O promoted synthesis of fluoroalkylated 3,3′,3′′-trisindolylmethanes from fluorocarboxylic acids and indoles

被引：2

作者：

Xu, Xin ^{[1
,2
,3
]}

Gao, Dandan ^{[1
,2
,3
]}

Wang, Jiahua ^{[1
,2
,3
]}

Tang, Xiang-Ying ^{[1
,2
,3
]}

Wang, Long ^{[1
,2
,3
]}

机构：

[1] Huazhong Univ Sci & Technol, Key Lab Mat Chem Energy Convers & Storage, Minist Educ, Wuhan 430074, Peoples R China

[2] Huazhong Univ Sci & Technol, Hubei Key Lab Bioinorgan Chem & Mat Med, Wuhan 430074, Peoples R China

[3] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 07期

基金：

中国国家自然科学基金;

关键词：

NATURAL-PRODUCTS; CATALYST; CHEMISTRY; BACTERIUM; MOLECULE; COMPLEX;

D O I：

10.1039/d2ob02241a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trisindolylmethanes (TIMs) exist in many bioactive natural products and are frequently applied in medicinal chemistry and materials science. Herein, a simple and efficient protocol promoted by B(C6F5)(3)center dot H2O for the synthesis of their fluoroalkylated analogues, fluoroalkylated 3,3 ',3 ''-TIMs, is reported for the first time. Easily accessible fluorocarboxylic acids are utilized as the fluoroalkyl sources, exhibiting an obvious fluorine effect. This convenient and green process features mild and metal-free conditions, easy scale-up, and an environmentally friendly byproduct.

引用

页码：1478 / 1486

页数：9

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