The B(C6F5)3•H2O promoted synthesis of fluoroalkylated 3,3′,3′′-trisindolylmethanes from fluorocarboxylic acids and indoles

被引：2
|
作者：
Xu, Xin [1 ,2 ,3 ]
Gao, Dandan [1 ,2 ,3 ]
Wang, Jiahua [1 ,2 ,3 ]
Tang, Xiang-Ying [1 ,2 ,3 ]
Wang, Long [1 ,2 ,3 ]
机构：
[1] Huazhong Univ Sci & Technol, Key Lab Mat Chem Energy Convers & Storage, Minist Educ, Wuhan 430074, Peoples R China
[2] Huazhong Univ Sci & Technol, Hubei Key Lab Bioinorgan Chem & Mat Med, Wuhan 430074, Peoples R China
[3] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 07期
基金：
中国国家自然科学基金;
关键词：
NATURAL-PRODUCTS; CATALYST; CHEMISTRY; BACTERIUM; MOLECULE; COMPLEX;
D O I：
10.1039/d2ob02241a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Trisindolylmethanes (TIMs) exist in many bioactive natural products and are frequently applied in medicinal chemistry and materials science. Herein, a simple and efficient protocol promoted by B(C6F5)(3)center dot H2O for the synthesis of their fluoroalkylated analogues, fluoroalkylated 3,3 ',3 ''-TIMs, is reported for the first time. Easily accessible fluorocarboxylic acids are utilized as the fluoroalkyl sources, exhibiting an obvious fluorine effect. This convenient and green process features mild and metal-free conditions, easy scale-up, and an environmentally friendly byproduct.
引用
收藏
页码：1478 / 1486
页数：9
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