Synthesis of novel ?-butyrolactone-based phenazine compounds via microwave-assisted multicomponent domino reactions

被引：2

作者：

Nguyen, Ha-Thanh ^{[1
,2
]}

Thi, Phuong Hoang ^{[1
]}

Le-Nhat-Thuy, Giang ^{[1
,2
]}

Thi, Quynh Giang Nguyen ^{[1
,2
]}

Nguyen, Tuan Anh ^{[1
]}

Thi, Tuyet Anh Dang ^{[1
,2
]}

Nguyen, Tuyen Van ^{[1
,2
]}

机构：

[1] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet St, Hanoi, Vietnam

[2] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, 18 Hoang Quoc Viet St, Hanoi, Vietnam

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2023年 / 58卷 / 12期

关键词：

gamma-butyrolactone; naphthoquinone; phenazine; microwave-assisted multicomponent reaction; ANTITUMOR-ACTIVITY; TOPOISOMERASE-I; GREEN SYNTHESIS; DERIVATIVES; INHIBITOR; FUNGUS; ANALOGS;

D O I：

10.1007/s10593-023-03152-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new and significative gamma-butyrolactone-based phenazines were synthesized through two-step one-pot five-component reactions of 2-hydroxy-1,4-naphthoquinone, a variety of aromatic aldehydes, benzene-1,2-diamine, tetronic acid, and ammonium acetate in glacial acetic acid. The synthesis proceeded via condensation, Michael addition, tautomerization sequence of steps. All the synthesized compounds were fully characterized by spectral data.

引用

页码：749 / 755

页数：7

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