Comparative features and outcomes of major neurological complications of COVID-19

被引：14

作者：

Beghi, Ettore ^{[1
]}

Moro, Elena ^{[2
]}

Davidescu, Eugenia Irene ^{[3
,4
]}

Popescu, Bogdan Ovidiu ^{[3
,4
]}

Grosu, Oxana ^{[5
]}

Valzania, Franco ^{[6
]}

Cotelli, Maria Sofia ^{[7
]}

Kiteva-Trenchevska, Gordana ^{[8
]}

Zakharova, Maria ^{[9
]}

Kovacs, Tibor ^{[10
]}

Armon, Carmel ^{[11
,12
]}

Brola, Waldemar ^{[13
]}

Yasuda, Clarissa Lin ^{[14
,15
]}

Maia, Luis F. ^{[16
]}

Lovrencic-Huzjan, Arijana ^{[17
]}

Laracho de Seabra, Mafalda Maria ^{[18
,19
]}

Avalos-Pavon, Rafael ^{[20
]}

Aamodt, Anne Hege ^{[21
]}

Meoni, Sara ^{[2
]}

Gryb, Victoria ^{[22
]}

Ozturk, Serefnur ^{[23
]}

Karadas, Omer ^{[24
]}

Krehan, Ingomar ^{[25
]}

Leone, Maurizio A. ^{[1
]}

Lolich, Maria ^{[26
]}

Bianchi, Elisa ^{[1
]}

Rass, Verena ^{[27
]}

Helbok, Raimund ^{[27
]}

Bassetti, Claudio L. A. ^{[28
]}

机构：

[1] Ist Ric Farmacol Mario Negri IRCCS, Milan, Italy

[2] Grenoble Alpes Univ, Ctr Hosp Univ Grenoble, Serv Neurol, Grenoble Inst Neurosci, Grenoble, France

[3] Colentina Clin Hosp, Neurol Dept, Bucharest, Romania

[4] Carol Davila Univ Med & Pharm, Dept Clin Neurosci, Bucharest, Romania

[5] Diomid Gherman Inst Neurol & Neurosurg, Kishinev, Moldova

[6] Azienda USL IRCCS Reggio Emilia, Neurol Unit, Neuromotor & Rehabil Dept, Reggio Emilia, Italy

[7] ASST Valcamonica, Neurol Unit, Brescia, Italy

[8] Univ Ss Cyril & Methodius, Univ Clin Neurol, Med Fac, Skopje, North Macedonia

[9] Dept Res Ctr Neurol, Moscow, Russia

[10] Semmelweis Univ Budapest, Budapest, Hungary

[11] Tel Aviv Univ, Sch Med, Tel Aviv, Israel

[12] Tel Aviv Univ, Shamir Assaf Harofeh Med Ctr, Tel Aviv, Israel

[13] Jan Kochanowski Univ Humanities & Sci, Specialist Hosp Konskie, Coll Med, Dept Neurol, Kielce, Poland

[14] CEPID BRAINN Brazilian Inst Neurosci & Neurotechn, Campinas, Brazil

[15] Univ Estadual Campinas, Campinas, Brazil

[16] Hosp Santo Antonio CHUP, Neurol Dept, Porto, Portugal

[17] UHC Sestre Milosrdnice, Dept Neurol, Zagreb, Croatia

[18] Ctr Hosp Univ Sao Joao, Dept Neurol, EPE, Porto, Portugal

[19] Univ Porto, Portugal Dept Clin Neurosci & Mental Hlth, Cardiovasc I&D Unit, Fac Med, Porto, Portugal

[20] Univ Autonoma San Luis Potosi, Fac Med, Neurol Serv, Hosp Cent, San Luis Potosi, San Luis Potosi, Mexico

[21] Oslo Univ Hosp, Dept Neurol, Oslo, Norway

[22] Ivano Frankivsk Natl Med Univ, Dept Neurol & Neurosurg, Ivano Frankivsk, Ukraine

[23] Selcuk Univ, Dept Neurol, Fac Med, Konya, Turkey

[24] Univ Hlth Sci, Gulhane Sch Med, Neurol Dept, Ankara, Turkey

[25] Kepler Univ Hosp, Dept Neurol, Linz, Austria

[26] European Acad Neurol, Vienna, Austria

[27] Med Univ Innsbruck, Dept Neurol, Neurocrit Care Unit, Innsbruck, Austria

[28] Univ Hosp Bern, Dept Neurol, Bern, Switzerland

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2023年 / 30卷 / 02期

关键词：

coronavirus; COVID-19; neurological complications; neurology; DISSEMINATED INTRAVASCULAR COAGULATION; HOSPITALIZED-PATIENTS; METAANALYSIS;

D O I：

10.1111/ene.15617

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose: The aim of this study was to assess the neurological complications of SARS-CoV-2 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations. Methods: The data source was a registry established by the European Academy of Neurology during the first wave of the COVID-19 pandemic. Neurologists collected data on patients with COVID-19 seen as in- and outpatients and in emergency rooms in 23 European and seven non-European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID-19 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute/subacute selected neurological manifestations in patients with COVID-19 were analysed, comparing individuals with and without each condition for several risk factors. Results: By July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex/unknown, aged 16-101 years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute/subacute neurological manifestations were cognitive dysfunction (N = 449, 29.5%), stroke (N = 392, 25.7%), sleep-wake disturbances (N = 250, 16.4%), dysautonomia (N = 224, 14.7%), peripheral neuropathy (N = 145, 9.5%), movement disorders (N = 142, 9.3%), ataxia (N = 134, 8.8%), and seizures (N = 126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non-neurological manifestations, extent of association with other acute/subacute neurological manifestations, and outcome. Conclusions: Patients with COVID-19 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID-19.

引用

页码：413 / 433

页数：21

共 32 条

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