Facile Synthesis and Antitumor Activity of o-Iodoaromatic Ether

被引：0

作者：

Mao, Xiaoxia ^{[1
]}

Zhang, Yuying ^{[1
]}

Wang, Keyang ^{[2
]}

Zhao, Guiqin ^{[1
]}

Zhou, Dejun ^{[1
]}

Cui, Zhengguo ^{[3
]}

机构：

[1] Chengde Med Univ, Inst Chinese Med, Lab Chinese Med Res & Dev HeBei Prov, Chengde 067000, Peoples R China

[2] Shandong Daguan Pharmaceut Technol Co Ltd, Jinan 250100, Shandong, Peoples R China

[3] Univ Fukui, Sch Med Sci, Dept Environm Hlth, 23-3 Matsuoka Shimoaizuki, Eiheiji, Fukui 9101193, Japan

来源：

LETTERS IN ORGANIC CHEMISTRY | 2024年 / 21卷 / 09期

关键词：

(diacetoxyiodo)arene; aromatic ether; apoptosis; U937; monocytes; acute myeloid leukemia; MALIGNANT PROGRESSION; ARYL ETHER; LEUKEMIA; PROMOTES; OXIDANT;

D O I：

10.2174/0115701786262911240121105544

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, an efficient method for the synthesis of one type of aromatic ether was introduced, and its antitumor activity was investigated. Specifically, (diacetoxyiodo)arene was prepared from 2-methyliodobenzene and used to oxidize the 4-nitrophenol to give the aromatic ether. Our study further found that aromatic ether has a strong apoptotic effect on U937 monocytes, suggesting that it might be developed as a new drug for the treatment of acute myeloid leukemia.

引用

页码：784 / 789

页数：6

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