Facile Synthesis and Antitumor Activity of o-Iodoaromatic Ether

被引：0
|
作者：
Mao, Xiaoxia [1 ]
Zhang, Yuying [1 ]
Wang, Keyang [2 ]
Zhao, Guiqin [1 ]
Zhou, Dejun [1 ]
Cui, Zhengguo [3 ]
机构：
[1] Chengde Med Univ, Inst Chinese Med, Lab Chinese Med Res & Dev HeBei Prov, Chengde 067000, Peoples R China
[2] Shandong Daguan Pharmaceut Technol Co Ltd, Jinan 250100, Shandong, Peoples R China
[3] Univ Fukui, Sch Med Sci, Dept Environm Hlth, 23-3 Matsuoka Shimoaizuki, Eiheiji, Fukui 9101193, Japan
来源：
LETTERS IN ORGANIC CHEMISTRY | 2024年 / 21卷 / 09期
关键词：
(diacetoxyiodo)arene; aromatic ether; apoptosis; U937; monocytes; acute myeloid leukemia; MALIGNANT PROGRESSION; ARYL ETHER; LEUKEMIA; PROMOTES; OXIDANT;
D O I：
10.2174/0115701786262911240121105544
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this study, an efficient method for the synthesis of one type of aromatic ether was introduced, and its antitumor activity was investigated. Specifically, (diacetoxyiodo)arene was prepared from 2-methyliodobenzene and used to oxidize the 4-nitrophenol to give the aromatic ether. Our study further found that aromatic ether has a strong apoptotic effect on U937 monocytes, suggesting that it might be developed as a new drug for the treatment of acute myeloid leukemia.
引用
收藏
页码：784 / 789
页数：6
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