Preoperative dietitian-led Very Low Calorie Diet (VLCD) Clinic for adults living with obesity undergoing gynaecology, laparoscopic cholecystectomy and hernia repair procedures: a pilot parallel randomised controlled trial

被引：0

作者：

Griffin, Sally B. ^{[1
,2
]}

Palmer, Michelle A. ^{[1
]}

Strodl, Esben ^{[3
]}

Lai, Rainbow ^{[1
]}

Chuah, Teong L. ^{[4
,5
,6
]}

Burstow, Matthew J. ^{[4
,7
]}

Ross, Lynda J. ^{[2
]}

机构：

[1] Logan Hosp, Dept Nutr & Dietet, Meadowbrook, Qld, Australia

[2] Queensland Univ Technol, Sch Exercise & Nutr Sci, Brisbane, Qld, Australia

[3] Queensland Univ Technol, Sch Psychol & Counselling, Brisbane, Qld, Australia

[4] Logan Hosp, Surg & Crit Care Serv, Meadowbrook, Qld, Australia

[5] Mater Hosp, Dept Surg, South Brisbane, Qld, Australia

[6] Univ Queensland, Mayne Acad Surg, Fac Med, St Lucia, Qld, Australia

[7] Griffith Univ, Sch Med & Dent, Gold Coast, Qld, Australia

来源：

BRITISH JOURNAL OF NUTRITION | 2024年 / 131卷 / 08期

关键词：

VLCD; VLED; Dietitian; Diet; Weight loss; Obesity; Prehabilitation; WEIGHT-LOSS; BARIATRIC SURGERY; BODY-COMPOSITION; SAMPLE-SIZE; OVERWEIGHT; HYSTERECTOMY; GUIDELINES; REDUCTION; NUTRITION; MASS;

D O I：

10.1017/S0007114524000114

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Obesity can increase the risk of postoperative complications. Despite increased demand for patients living with obesity to lose weight prior to common surgical procedures, the impact of intentional weight loss on surgical outcomes is largely unknown. We aimed to conduct a pilot study to assess the feasibility of a full-scale randomised controlled trial (RCT) to examine the effect of preoperative dietitian-led Very Low Calorie Diet (VLCD) Clinic on surgical outcomes in gynaecology and general surgeries. Between August 2021 and January 2023, a convenience sample of adults living with obesity (BMI >= 30 kg/m(2)) awaiting gynaecology, laparoscopic cholecystectomy and ventral hernia repair procedures were randomised to dietitian-led VLCD (800-1000 kcal using meal replacements and allowed foods), or control (no dietary intervention), 2-12 weeks preoperatively. Primary outcome was feasibility (recruitment, adherence, safety, attendance, acceptability and quality of life (QoL)). Secondary outcomes were anthropometry and 30-d postoperative outcomes. Outcomes were analysed as intention-to-treat. Fifty-one participants were recruited (n 23 VLCD, n 28 control), mean 48 (SD 13) years, 86 % female, and mean BMI 35 center dot 8 (SD 4 center dot 6) kg/m(2). Recruitment was disrupted by COVID-19, but other thresholds for feasibility were met for VLCD group: high adherence without unfavourable body composition change, high acceptability, improved pre/post QoL (22 center dot 1 +/- 15 points, < 0 center dot 001), with greater reductions in weight (-5 center dot 5 kg VLCD v. -0 center dot 9 kg control, P < 0 center dot 05) waist circumference (-6 center dot 6 cm VLCD v. +0 center dot 6 control, P < 0 center dot 05) and fewer 30-d complications (n 4/21) than controls (n 8/22) (P > 0 center dot 05). The RCT study design was deemed feasible in a public hospital setting. The dietitian-led VLCD resulted in significant weight loss and waist circumference reduction compared with a control group, without unfavourable body composition change and improved QoL.

引用

页码：1436 / 1446

页数：11