Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort

被引：10

作者：

Casco, Nicolas ^{[1
]}

Levi Jorge, Alberto ^{[1
]}

Juan Palmero, Domingo ^{[1
]}

Alffenaar, Jan-Willem ^{[2
,3
,4
]}

Fox, Greg J. ^{[5
]}

Ezz, Wafaa ^{[5
]}

Cho, Jin-Gun ^{[2
,6
,7
]}

Denholm, Justin ^{[8
,9
]}

Skrahina, Alena ^{[10
]}

Solodovnikova, Varvara ^{[10
]}

Arbex, Marcos Abdo ^{[11
]}

Alves, Tatiana ^{[12
]}

Rabahi, Marcelo Fouad ^{[13
]}

Pereira, Giovana Rodrigues ^{[14
]}

Sales, Roberta ^{[15
]}

Silva, Denise Rossato ^{[16
]}

Saffie, Muntasir M. ^{[17
]}

Escobar Salinas, Nadia ^{[18
]}

Caamano Miranda, Ruth ^{[19
]}

Cisterna, Catalina ^{[19
]}

Concha, Clorinda ^{[19
]}

Fernandez, Israel ^{[19
]}

Villalon, Claudia ^{[19
]}

Guajardo Vera, Carolina ^{[19
]}

Gallegos Tapia, Patricia ^{[19
]}

Cancino, Viviana ^{[20
]}

Carbonell, Monica ^{[20
]}

Cruz, Arturo ^{[20
]}

Munoz, Eduardo ^{[20
]}

Munoz, Camila ^{[20
]}

Navarro, Indira ^{[20
]}

Pizarro, Rolando ^{[20
]}

Cristina Sanchez, Gloria Pereira ^{[20
]}

Vergara Riquelme, Maria Soledad ^{[20
]}

Vilca, Evelyn ^{[20
]}

Soto, Aline ^{[20
]}

Flores, Ximena ^{[21
]}

Garavagno, Ana ^{[21
]}

Hartwig Bahamondes, Martina ^{[21
]}

Moyano Merino, Luis ^{[21
]}

Maria Pradenas, Ana ^{[21
]}

Espinoza Revillot, Macarena ^{[21
]}

Rodriguez, Patricia ^{[21
]}

Serrano Salinas, Angeles ^{[22
]}

Taiba, Carolina ^{[22
]}

Farias Valdes, Joaquin ^{[23
]}

Navarro Subiabre, Jorge ^{[24
]}

Ortega, Carlos ^{[25
]}

Palma, Sofia ^{[26
]}

Perez Castillo, Patricia ^{[27
]}

机构：

[1] Inst Tisioneumonol Prof Dr R Vaccarezza, Buenos Aires, Argentina

[2] Univ Sydney, Sydney Inst Infect Dis, Sydney, Australia

[3] Univ Sydney, Sch Pharm, Fac Med & Hlth, Sydney, Australia

[4] Westmead Hosp, Sydney, Australia

[5] Univ Sydney, Sydney Sch Med, Fac Med & Hlth, Sydney, Australia

[6] Parramatta Chest Clin, Parramatta, Australia

[7] Westmead Hosp, Westmead, Australia

[8] Melbourne Hlth, Victorian TB Program, Melbourne, Vic, Australia

[9] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Infect Dis, Parkville, Australia

[10] Republican Res & Pract Ctr Pulmonol & TB, Minsk, BELARUS

[11] Univ Araraquara, Fac Med, Area Temat Pneumol, Araraquara, Brazil

[12] Univ Fed Bahia, Salvador, Brazil

[13] Univ Fed Goias, Fac Med, Goiania, Go, Brazil

[14] Secretaria Municipal Saude, Lab Municipal Alvorada, Alvorada, Brazil

[15] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Inst Coracao,Div Pneumol, Sao Paulo, Brazil

[16] Univ Fed Rio Grande do Sul UFRGS, Fac Med, Porto Alegre, Brazil

[17] McMaster Univ, Div Respirol, Hamilton, ON, Canada

[18] Minist Salud Chile, Programa Nacl TB, Santiago, Chile

[19] Serv Salud Metropolitano Cent, Santiago, Chile

[20] Serv Salud Metropolitano Sur, Santiago, Chile

[21] Serv Salud Metropolitano Oriente, Providencia, Chile

[22] Serv Salud Metropolitano Occidente, Santiago, Chile

[23] Serv Salud Iquique, Iquique, Chile

[24] Serv Salud Valparaiso San Antonio, Valparaiso, Chile

[25] Serv Salud Concepcion, Concepcion, Chile

[26] Hosp DIPRECA, Las Condes, Chile

[27] Serv Salud Antofagasta, Antofagasta, Chile

[28] Serv Salud Magallanes, Punta Arenas, Chile

[29] Serv Salud Talcahuano, Talcahuano, Chile

[30] Serv Salud Arica, Arica, Chile

[31] Fudan Univ, Huashan Hosp, Dept Infect Dis, Shanghai, Peoples R China

[32] Minist Salud & Protecc Social, Bogota, Colombia

[33] Secretaria Salud Dept, Cauca, Colombia

[34] Univ Cauca, Dept Med Interna, Grp Invest TB, Popayan, Colombia

[35] Catholic Univ Cuenca, Cuenca, Ecuador

[36] WHO Reg Off Eastern Mediterranean Reg, Cairo, Egypt

[37] CHU Amiens Picardie, Resp Dept, Amiens, France

[38] Picardie Jules Verne Univ, UR 4294, AGIR, Amiens, France

[39] Nantes Univ, CHU Nantes, Inst Thorax, Serv Pneumol, Nantes, France

[40] Grp Hosp Sud Ile de France GHSIF, Serv Pneumol, Melun, France

[41] Intermunicipal Hosp Ctr Creteil, Dept Internal Med, Creteil, France

[42] North Cardiol Ctr, Pneumol Dept, St Denis, France

[43] Hop Instruct Armees Percy, Dept Pneumol, Clamart, France

[44] Hop Univ Henri Mondor, AP HP, Unite Pneumol, Creteil, France

[45] Univ Paris Est Creteil, Fac Sante, INSERM, IMRB, Creteil, France

[46] Aristotle Univ Thessaloniki, Pulm Dept, Thessaloniki, Greece

[47] Univ Gamal Abdel Nasser Conakry, CHU Conakry, Fac Sci & Tech Sante, Serv Pneumophtisiol, Conakry, Guinea

[48] Hop Natl Ignace Deen, Conakry, Guinea

[49] Damien Fdn, Conakry, Guinea

[50] Secretaria Salud Honduras, Natl TB Programme, Tegucigalpa, Honduras

来源：

EUROPEAN RESPIRATORY JOURNAL | 2023年 / 62卷 / 05期

关键词：

EXTREMELY PRETERM; LUNG-FUNCTION; SCHOOL-AGE; BIRTH; EXERCISE; CHILDREN; INFANTS; IMPAIRMENT; SURVIVORS; MEMBRANE;

D O I：

10.1183/13993003.00925-2023

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03-1.07), HIV infection (HR 2.29, 95% CI 1.02-5.16) and invasive ventilation (HR 4.28, 95% CI 2.34-7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02-1.04), male sex (HR 2.21, 95% CI 1.24-3.91), oxygen requirement (HR 7.93, 95% CI 3.44- 18.26) and invasive ventilation (HR 2.19, 95% CI 1.36-3.53). Conclusions In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.

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页数：12

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