Relation of testosterone level and other factors with bone mineral density in male kidney transplant recipients: a cross-sectional study

被引:1
|
作者
Naga, Yasmine Salah [1 ]
Sharaki, Ola Atef [2 ]
Azzam, Eman Zaki [3 ]
Farag, Eman Mohamed Mostafa [4 ]
Zeid, Montasser Mohamed Hussein [1 ]
机构
[1] Alexandria Univ, Fac Med, Internal Med Dept, Nephrol Unit, Alexandria, Egypt
[2] Alexandria Univ, Fac Med, Clin & Chem Pathol Dept, Alexandria, Egypt
[3] Alexandria Univ, Fac Med, Internal Med Dept, Endocrinol Unit, Alexandria, Egypt
[4] Alexandria Univ, Alexandria, Egypt
关键词
Bone mineral density; Testosterone; Kidney transplantation; RISK-FACTORS; RAPID LOSS; MASS; DETERMINANTS;
D O I
10.1186/s12882-023-03318-8
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
BackgroundAlthough testosterone has a pivotal role in bone health, its correlation with bone mineral density (BMD) is understudied in kidney transplant recipients who are at high risk of osteoporosis. This study aimed to elucidate if there is any correlation between serum free testosterone and BMD in this population.Patients and methodsSixty male kidney transplant recipients were enrolled in this cross-sectional study, and they were subjected to history taking, clinical examination, and laboratory investigations (including total and free testosterone). BMD was assessed in three regions (forearm, hip, and lumbar spine) using DEXA scan.ResultsThe mean age of the included patients was 45.55 & PLUSMN; 13.58 years. Serum total and free testosterone had mean values of 5.17 & PLUSMN; 1.4 ng/ml and 95.46 & PLUSMN; 28.24 pg/ml, respectively, with all levels within the normal range. DEXA scan detected osteoporosis and osteopenia in 9 (15%) and 30 (50%) patients in the lumbar region, 3 (5%) and 36 (60%) in the hip region, as well as 21 (35%) and 33 (55%) in the forearm region, respectively. BMD of the lumbar region had a significant positive correlation with free testosterone, phosphorus, and eGFR, while it had a significant negative correlation with platelets and patient age. BMD of the hip region was positively correlated with serum phosphorus, parathyroid hormone, and duration since the transplant, whereas it was negatively correlated with platelets and total testosterone level. BMD of the forearm had a significant positive correlation with eGFR, whereas it had a significant negative correlation with age and duration since transplantation. In addition, forearm BMD was significantly lower in patients with a radiocephalic AVF.ConclusionEven within the normal range, free testosterone has a significant positive correlation with lumbar spine BMD with no significant association with the forearm or hip BMD.
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页数:8
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