Proline-Catalyzed Diastereoselective Synthesis of Dihydroquinolinyl-Spirooxindole via Aza-Michael/Aldol Reaction

被引：2

作者：

Enagandhula, Damodar ^{[1
,2
]}

Adepu, Raju ^{[2
,3
]}

Mainkar, Prathama S. ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

[3] CSIR Indian Inst Chem Technol, Dept Nat Prod & Med Chem, Hyderabad 500007, India

来源：

SYNTHESIS-STUTTGART | 2023年 / 55卷 / 20期

关键词：

l; -Proline; organocatalytic reaction; spirooxindole; aza-Michael-; addition; aldol condensation; ENANTIOSELECTIVE CONSTRUCTION; SPIROCYCLIC OXINDOLE; ASYMMETRIC-SYNTHESIS; SCAFFOLDS; EFFICIENT; STEREOCENTERS; DERIVATIVES;

D O I：

10.1055/a-2116-5517

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient diastereoselective synthesis of 1',4'-dihydro-2'H-spiro[indoline-3,3'-quinolin]-2-one derivatives was achieved using catalytic amount of L-proline. The key reactions involved in the present tandem reaction are aza-Michael addition and aldol reaction. This atom economic reaction proceeded under mild conditions with a broad substrate scope and excellent diastereoselectivity in good to excellent yields.

引用

页码：3281 / 3288

页数：8

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