Alterations of gut microbiome and metabolism induced by inulin associated with weight loss in obese female mice

被引：1
作者：
Wu, Zeang [1 ]
Zhang, Mei [2 ,3 ]
Deng, Yuhong [1 ]
Zhou, Guangyuan [4 ]
Yang, Meng [5 ]
Wang, Haixia [2 ,3 ]
机构：
[1] Shihezi Univ, Affiliated Hosp 1, Shihezi, Peoples R China
[2] Xinjiang Prod & Construct Corps, Key Lab Prevent & Control Emerging Infect Dis & Pu, Urumqi, Xinjiang, Peoples R China
[3] Shihezi Univ, Sch Med, Shihezi, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Wuhan, Peoples R China
[5] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Hlth Care Hosp, Inst Maternal & Child Hlth,Tongji Med Coll, Wuhan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2023年 / 74卷 / 05期
关键词：
Obesity; inulin; gut microbiota; Muribaculaceae; monoacylglycerol; SERUM;
D O I：
10.1080/09637486.2023.2235901
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Our previous work revealed the microbiota-dependent beneficial effects of inulin in obese male mice, but the effects in obese female mice were not determined. High-fat diet (HFD)-induced obese female mice were switched to normal diets and gavaged with normal saline or inulin for 10 weeks. Inulin supplementation significantly accelerated weight loss and reversed HFD-induced gut microbiota dysbiosis in obese female mice, and also reduced the ratio of Firmicutes/Bacteroidetes and enriched the abundance of norank_f_Muribaculaceae and Alistipes. In addition, 52 key serum metabolites were distinctly altered after inulin supplementation. Among them, andrographolide and monoacylglycerols (18:4) increased more than 9-fold and 14-fold, respectively, while phosphatidylcholine (PC) (18:1e/2:0), PC (20:1/20:2) and PC (19:1/19:1) decreased. In conclusion, gut microbiota and metabolites were closely associated with the beneficial effects of inulin in accelerating weight loss in obese female mice.
引用
收藏
页码：606 / 620
页数：15
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