Design and synthesis of a NAD(P)H:quinone oxidoreductase 1-activatable photosensitiser for controlled photodynamic therapy

被引：8
|
作者：
Xue, Evelyn Y. [1 ]
Kang, Fangyuan [1 ]
Zhou, Yimin [1 ]
Ng, Dennis K. P. [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 46期
关键词：
STRATEGY; NQO1;
D O I：
10.1039/d3cc00683b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The utilisation of enzymes as stimuli can activate theranostic agents in a highly specific manner. We report herein a far-red-absorbing boron dipyrromethene-based photosensitiser that is responsive towards the cancer-associated human NAD(P)H:quinone oxidoreductase 1, enabling the controlled restoration of photodynamic activity for selective elimination of cancer cells.
引用
收藏
页码：7056 / 7059
页数：4
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