PARP1 and HPF1 team up to flag down DNA-repair machinery

被引：1
|
作者：
Rudolph, Johannes [1 ]
Luger, Karolin [1 ]
机构：
[1] Univ Colorado Boulder, Boulder, CO 80309 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2023年 / 30卷 / 05期
关键词：
ADP-RIBOSYLATION; POLY(ADP-RIBOSE); INSIGHTS;
D O I：
10.1038/s41594-023-00987-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The enzymatic activity of PARP1-which adds chains of (poly-ADP)-ribose (PAR) to proteins-initiates DNA repair by leading to more-accessible chromatin and recruitment of PAR-dependent DNA-repair proteins. New work shows that these PARP1-catalysed functions are redirected by the auxiliary factor HPF1 in cells.
引用
收藏
页码：568 / 569
页数：2
相关论文
共 50 条
  • [31] Repair pathway for PARP-1 DNA-protein crosslinks
    Prasad, Rajendra
    Horton, Julie K.
    Dai, Da-Peng
    Wilson, Samuel H.
    DNA REPAIR, 2019, 73 : 71 - 77
  • [32] PARP1-dependent DNA-protein crosslink repair
    Fabian, Zita
    Kakulidis, Ellen S.
    Hendriks, Ivo A.
    Kuhbacher, Ulrike
    Larsen, Nicolai B.
    Oliva-Santiago, Marta
    Wang, Junhui
    Leng, Xueyuan
    Dirac-Svejstrup, A. Barbara
    Svejstrup, Jesper Q.
    Nielsen, Michael L.
    Caldecott, Keith
    Duxin, Julien P.
    NATURE COMMUNICATIONS, 2024, 15 (01)
  • [33] TSG101 associates with PARP1 and is essential for PARylation and DNA damage-induced NF-κB activation
    Tufan, Ahmet Bugra
    Lazarow, Katina
    Kolesnichenko, Marina
    Sporbert, Anje
    von Kries, Jens Peter
    Scheidereit, Claus
    EMBO JOURNAL, 2022, 41 (21)
  • [34] ANP32B promotes colorectal cancer cell progression and reduces cell sensitivity to PRAP1 inhibitor through up-regulating HPF1
    Yang, Li -Li
    Li, Meng
    Huang, Wei
    Ren, Peng -Tao
    Yan, Qing -Hui
    Hao, Ying-Hao
    HELIYON, 2024, 10 (01)
  • [35] PARP1 is activated by membrane damage and is involved in membrane repair through poly(ADP-ribosyl)ation
    Mashimo, Masato
    Kita, Momoko
    Nobeyama, Akari
    Nomura, Atsuo
    Fujii, Takeshi
    GENES TO CELLS, 2022, 27 (04) : 305 - 312
  • [36] The Role of PARP1 and PAR in ATP-Independent Nucleosome Reorganisation during the DNA Damage Response
    Belousova, Ekaterina A.
    Lavrik, Olga I.
    GENES, 2023, 14 (01)
  • [37] Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation
    Nalabothula, Narasimharao
    Al-Jumaily, Taha
    Eteleeb, Abdallah M.
    Flight, Robert M.
    Shao Xiaorong
    Moseley, Hunter
    Rouchka, Eric C.
    Fondufe-Mittendorf, Yvonne N.
    PLOS ONE, 2015, 10 (08):
  • [38] Multifaceted Role of PARP1 in Maintaining Genome Stability Through Its Binding to Alternative DNA Structures
    Laspata, Natalie
    Muoio, Daniela
    Fouquerel, Elise
    JOURNAL OF MOLECULAR BIOLOGY, 2024, 436 (01)
  • [39] Beyond DNA repair, the immunological role of PARP-1 and its siblings
    Rosado, Maria Manuela
    Bennici, Elisabetta
    Novelli, Flavia
    Pioli, Claudio
    IMMUNOLOGY, 2013, 139 (04) : 428 - 437
  • [40] Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2
    Deeksha, Waghela
    Rajakumara, Eerappa
    DNA REPAIR, 2024, 133
12345