PARP1 and HPF1 team up to flag down DNA-repair machinery

被引：3

作者：

Rudolph, Johannes ^{[1
]}

Luger, Karolin ^{[1
]}

机构：

[1] Univ Colorado Boulder, Boulder, CO 80309 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2023年 / 30卷 / 05期

关键词：

ADP-RIBOSYLATION; POLY(ADP-RIBOSE); INSIGHTS;

D O I：

10.1038/s41594-023-00987-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The enzymatic activity of PARP1-which adds chains of (poly-ADP)-ribose (PAR) to proteins-initiates DNA repair by leading to more-accessible chromatin and recruitment of PAR-dependent DNA-repair proteins. New work shows that these PARP1-catalysed functions are redirected by the auxiliary factor HPF1 in cells.

引用

收藏

页码：568 / 569

页数：2

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