Research progress and insights on the role of ferroptosis in wound healing

被引：14
作者：
Bi, Minglei [1 ]
Li, Danyi [2 ]
Zhang, Jin [1 ]
机构：
[1] Lanzhou Univ Second Hosp, Dept Plast Surg, Lanzhou, Peoples R China
[2] Jiading Cent Hosp Univ Med & Hlth Sci, Dept Ophthalmol, Shanghai, Peoples R China
来源：
INTERNATIONAL WOUND JOURNAL | 2023年 / 20卷 / 06期
关键词：
biomaterials; diabetic wound; ferroptosis; iron metabolism; lipid peroxidation; wound healing; NONAPOPTOTIC CELL-DEATH; SIGNALING PATHWAY; IRON; DEFEROXAMINE; PROLIFERATION; MACROPHAGES; METABOLISM; ACTIVATION; PYROPTOSIS; PHYSIOLOGY;
D O I：
10.1111/iwj.14102
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Ferroptosis is a newly discovered cell death type which is different from apoptosis, autophagy, pyroptosis as well as necrosis in the following aspects: morphology, biochemistry, gene and regulatory mechanisms. Ferroptosis is regulated by multiples of mechanisms such as system Xc(-) mechanism, glutathione peroxidase 4 (GPX4) mechanism, iron metabolism and lipid metabolism. Currently, ferroptosis has been revealed to be significant in wound healing such as diabetic wound, irradiated wound and ultraviolet (UV)-driven wound. Hence, how to intervene in the pathogenesis as well as the development of wounds and promote the wound healing by the regulation of ferroptosis have become a research hotspot. This review systematically summarises the latest scientific advances of ferroptosis and wound healing fields, with hoping to propose a new insight and advance in the wound treatment.
引用
收藏
页码：2473 / 2481
页数：9
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