Aminotetrazole Synthesis from Secondary Amides by C-C Bond Nitrogenation

被引：0

作者：

Zhang, Cheng ^{[1
]}

Liu, Jianzhong ^{[1
]}

Cheng, Zengrui ^{[1
]}

Li, Junhua ^{[1
]}

Song, Song ^{[1
]}

Jiao, Ning ^{[1
,2
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Xue Yuan Rd 38, Beijing 100191, Peoples R China

[2] East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

来源：

SYNLETT | 2023年 / 34卷 / 12期

基金：

国家重点研发计划;

关键词：

aminotetrazoles; secondary amides; C-C bond cleavage; rearrangement; nitrogenation; DIRECT TRANSFORMATION; METHYL KETONES; CARBON; ACTIVATION; FUNCTIONALIZATION; CLEAVAGE; ROUTE; MILD;

D O I：

10.1055/a-2006-4548

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The development of novel methods for the preparation of aminotetrazoles is of long-standing interest to chemists due to the great importance of these compounds in chemistry and biology. Here, we report an efficient method for the preparation of aminotetrazoles from secondary amides by selective C-C bond cleavage. Compared with the conventional laborious and cumbersome approaches to aminotetrazoles, this chemistry provides a highly efficient nitrogenation strategy, with the installation of four nitrogen atoms into a secondary amide in one step.

引用

页码：1534 / 1538

页数：5

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