New benzaldehyde derivatives from the fruiting bodies of Hericium erinaceus with cytotoxic activity

被引：6

作者：

Ruan, Yang ^{[1
]}

Han, Chunguang ^{[1
]}

Wang, Dongmei ^{[1
]}

Inoue, Yuka ^{[1
]}

Amen, Yhiya ^{[2
]}

Othman, Ahmed ^{[1
,3
]}

Mittraphab, Yanisa ^{[1
]}

Nagata, Maki ^{[1
]}

Shimizu, Kuniyoshi ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Bioresource & Bioenvironm Sci, Dept Agroenvironm Sci, Fukuoka, Japan

[2] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura, Egypt

[3] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy & Med Plants, Cairo, Egypt

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 24期

关键词：

Hericium erinaceus; mushroom; hericenones; anticancer; AROMATIC-COMPOUNDS; MUSHROOM; IDENTIFICATION; COMPOUND;

D O I：

10.1080/14786419.2023.2169687

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four new natural compounds named hericenone O (1), hericenone P (2), hericenone Q (3), and hericenone R (4), two of them were reported synthetically (3-4), together with eleven known compounds were isolated from the fruiting bodies of Hericium erinaceus. The chemical structures of the isolated compounds were elucidated by using NMR analysis and mass spectrometry, as well as comparisons with the reported data in the literature. The bioactivity evaluation revealed that hericenone Q showed significant cytotoxic activity against Hep-G2 with IC50 values of 23.89 mu M, and against HCT-116 with IC50 values of 65.64 mu M.

引用

页码：4089 / 4098

页数：10

共 17 条

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