TH17 cell: a double-edged sword in the development of inflammatory bowel disease

被引：2

作者：

Wen, Yue ^{[1
]}

Wang, Han ^{[1
]}

Tian, Dean ^{[2
]}

Wang, Ge ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Gastroenterol, Wuhan 430000, Peoples R China

来源：

THERAPEUTIC ADVANCES IN GASTROENTEROLOGY | 2024年 / 17卷

基金：

中国国家自然科学基金;

关键词：

cytokines; inflammatory bowel disease; intestinal fibrosis; plasticity; Th17; cells; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; SEGMENTED FILAMENTOUS BACTERIA; PATHOGENIC T(H)17 CELLS; GENOME-WIDE ASSOCIATION; CROHNS-DISEASE; TGF-BETA; INTESTINAL INFLAMMATION; SUPPRESSIVE FUNCTION; LAMINA PROPRIA;

D O I：

10.1177/17562848241230896

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease (IBD) is a chronic nonspecific inflammatory disease of the gastrointestinal tract, and its pathogenesis has not been fully understood. Extensive dysregulation of the intestinal mucosal immune system is critical in the development and progression of IBD. T helper (Th) 17 cells have the characteristics of plasticity. They can transdifferentiate into subpopulations with different functions in response to different factors in the surrounding environment, thus taking on different roles in regulating the intestinal immune responses. In this review, we will focus on the plasticity of Th17 cells as well as the function of Th17 cells and their related cytokines in IBD. We will summarize their pathogenic and protective roles in IBD under different conditions, respectively, hoping to further deepen the understanding of the pathological mechanisms underlying IBD and provide insights for future treatment.

引用

页数：20

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