Developments in pharmacogenetics, pharmacogenomics, and personalized medicine

被引：9

作者：

Abad-Santos, Francisco ^{[1
,8
]}

Alino, Salvador F. ^{[2
]}

Borobia, Alberto M. ^{[3
]}

Garcia-Martin, Elena ^{[4
]}

Gasso, Patricia ^{[5
]}

Maronas, Olalla ^{[6
]}

Agundez, Jose A. G. ^{[7
]}

机构：

[1] Univ Autonoma Madrid UAM, Hosp Univ La Princesa, Clin Pharmacol Dept, CIBEREHD,Inst Invest Sanit Princesa IP, Madrid, Spain

[2] Univ Valencia, Fac Med, Dept Pharmacol, Gene Therapy & Pharmacogen Grp, Av Blasco Ibanez 15, Valencia 46010, Spain

[3] La Paz Univ Hosp, Univ Autonoma Madrid UAM, Sch Med, Clin Pharmacol Dept,IdiPAZ, Madrid, Spain

[4] Univ Extremadura, Dept Pharmacol, Avda Univ S-N, Caceres 10071, Spain

[5] Univ Barcelona, Fac Med & Hlth Sci, Basic Clin Practice Dept, Barcelona Clin Schizophrenia Unit BCSU,IDIBAPS,CIB, Barcelona, Spain

[6] Santiago Univ Hosp, Publ Fdn Genom Med, Santiago Hlth Res Inst IDIS, Genom Med Grp Pharmacogenet & Drug Discovery GenDe, Galicia, Spain

[7] Univ Inst Mol Pathol Biomarkers, Univ Extremadura, Avda Ciencias S-N, Caceres 10071, Spain

[8] Univ Autonoma Madrid UAM, Hosp Univ La Princesa, Clin Pharmacol Dept, CIBEREHD,Inst Invest Sanit Princesa IP, Diego Leon 62, Madrid 28006, Spain

来源：

PHARMACOLOGICAL RESEARCH | 2024年 / 200卷

关键词：

Pharmacogenetics; Pharmacogenomics; Adverse drug reactions; Polymorphic drug metabolism; Clinical practice; NONSYNONYMOUS POLYMORPHISMS; IMPLEMENTATION CONSORTIUM; EXTRAPYRAMIDAL SYMPTOMS; TRANSPLANT RECIPIENTS; PLASMA-CONCENTRATIONS; CLINICAL-PRACTICE; DIAMINE-OXIDASE; GENES REVEALS; VARIABILITY; VARIANTS;

D O I：

10.1016/j.phrs.2024.107061

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The development of Pharmacogenetics and Pharmacogenomics in Western Europe is highly relevant in the worldwide scenario. Despite the usually low institutional support, many research groups, composed of basic and clinical researchers, have been actively working for decades in this field. Their contributions made an international impact and paved the way for further studies and pharmacogenomics implementation in clinical practice. In this manuscript, that makes part of the Special Issue entitled Spanish Pharmacology, we present an analysis of the state of the art of Pharmacogenetics and Pharmacogenomics research in Europe, we compare it with the developments in Spain, and we summarize the most salient contributions since 1988 to the present, as well as recent developments in the clinical application of pharmacogenomics knowledge. Finally, we present some considerations on how we could improve translation to clinical practice in this specific scenario.

引用

页数：10

共 118 条

[1] GENETIC-BASIS FOR DIFFERENCES IN DEBRISOQUIN POLYMORPHISM BETWEEN A SPANISH AND OTHER WHITE-POPULATIONS [J].