Dyschromatopsia: a comprehensive analysis of mechanisms and cutting-edge treatments for color vision deficiency

被引:3
|
作者
Yang, Zihao [1 ,2 ]
Yan, Lin [1 ,2 ]
Zhang, Wenliang [1 ,2 ]
Qi, Jia [1 ,2 ]
An, Wenjing [1 ,2 ]
Yao, Kai [1 ,2 ]
机构
[1] Wuhan Univ Sci & Technol, Inst Visual Neurosci & Stem Cell Engn, Wuhan, Peoples R China
[2] Wuhan Univ Sci & Technol, Coll Life Sci & Hlth, Wuhan, Peoples R China
基金
中国国家自然科学基金;
关键词
color blindness; achromatopsia; cone; mechanism; treatment; ENDOPLASMIC-RETICULUM STRESS; LOCUS-CONTROL REGION; CONE PHOTORECEPTOR DEGENERATION; GENOTYPE-PHENOTYPE CORRELATION; UNFOLDED PROTEIN RESPONSE; VISUAL PIGMENT; GENE-THERAPY; MOUSE MODEL; CGMP PHOSPHODIESTERASE; ALPHA-SUBUNIT;
D O I
10.3389/fnins.2024.1265630
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Color blindness is a retinal disease that mainly manifests as a color vision disorder, characterized by achromatopsia, red-green color blindness, and blue-yellow color blindness. With the development of technology and progress in theory, extensive research has been conducted on the genetic basis of color blindness, and various approaches have been explored for its treatment. This article aims to provide a comprehensive review of recent advances in understanding the pathological mechanism, clinical symptoms, and treatment options for color blindness. Additionally, we discuss the various treatment approaches that have been developed to address color blindness, including gene therapy, pharmacological interventions, and visual aids. Furthermore, we highlight the promising results from clinical trials of these treatments, as well as the ongoing challenges that must be addressed to achieve effective and long-lasting therapeutic outcomes. Overall, this review provides valuable insights into the current state of research on color blindness, with the intention of informing further investigation and development of effective treatments for this disease.
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收藏
页数:18
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