Optimal control analysis of a transmission interruption model for the soil-transmitted helminth infections in Kenya

被引：0
作者：
Okoyo, Collins [1 ,2 ,3 ]
Orowe, Idah [1 ]
Onyango, Nelson [1 ]
Montresor, Antonio [4 ]
Mwandawiro, Charles [2 ]
Medley, Graham F. [5 ]
机构：
[1] Univ Nairobi, Sch Math, Nairobi, Kenya
[2] Kenya Med Res Inst KEMRI, Eastern & Southern Afr Ctr Int Parasite Control ES, Nairobi, Kenya
[3] Kenya Med Res Inst KEMRI, Dept Epidemiol Stat & Informat DESI, Nairobi, Kenya
[4] WHO, Dept Control Neglected Trop Dis, Geneva, Switzerland
[5] London Sch Hyg & Trop Med LSHTM, Fac Publ Hlth & Policy, London, England
来源：
CURRENT RESEARCH IN PARASITOLOGY & VECTOR-BORNE DISEASES | 2023年 / 4卷
基金：
英国惠康基金;
关键词：
Mathematical model; Optimal control; Soil-transmitted helminthiasis; Neglected tropical diseases; Kenya; SENSITIVITY-ANALYSIS; MATHEMATICAL-MODELS;
D O I：
10.1016/j.crpvbd.2023.100162
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Kenya is among the countries endemic for soil-transmitted helminthiasis (STH) with over 66 subcounties and over 6 million individuals being at-risk of infection. Currently, the country is implementing mass drug administration (MDA) to all the at-risk groups as the mainstay control strategy. This study aimed to develop and analyze an optimal control (OC) model, from a transmission interruption model, to obtain an optimal control strategy from a mix of three strategies evaluated. The study used the Pontryagin's maximum principle to solve, numerically, the OC model. The analysis results clearly demonstrated that water and sanitation when implemented together with the MDA programme offer the best chances of eliminating these tenacious and damaging parasites. Thus, we advocate for optimal implementation of the combined mix of the two interventions in order to achieve STH elimination in Kenya, and globally, in a short implementation period of less than eight years.
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页数：9
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