Increasing Pancreatic Cancer Incidence in Young Women in the United States: A Population-Based Time-Trend Analysis, 2001-2018

被引：1

作者：

Abboud, Yazan ^{[1
]}

Samaan, Jamil S. ^{[2
]}

Oh, Janice ^{[2
]}

Jiang, Yi ^{[1
]}

Randhawa, Navkiran ^{[3
]}

Lew, Daniel ^{[1
]}

Ghaith, Jenan ^{[1
]}

Pala, Pranav ^{[4
]}

Leyson, ChristineAnn ^{[1
]}

Watson, Rabindra ^{[1
]}

Liu, Quin ^{[1
]}

Park, Kenneth ^{[1
]}

Paski, Shirley ^{[1
]}

Osipov, Arsen ^{[5
]}

Larson, Brent K. ^{[6
]}

Hendifar, Andrew ^{[5
]}

Atkins, Katelyn ^{[7
]}

Nissen, Nicholas N. ^{[8
]}

Li, Debiao ^{[9
]}

Pandol, Stephen J. ^{[1
]}

Lo, Simon K. ^{[1
]}

Gaddam, Srinivas ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Karsh Div Gastroenterol & Hepatol, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA

[3] Franciscan Hlth, Dept Internal Med, Olympia Fields, IL USA

[4] Kamineni Acad Med Sci & Res Ctr, Hyderabad, India

[5] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Dept Med, Los Angeles, CA 90048 USA

[6] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

[7] Cedars Sinai Med Ctr, Dept Radiat Oncol, Los Angeles, CA 90048 USA

[8] Cedars Sinai Med Ctr, Dept Pancreat & Biliary Surg, Los Angeles, CA 90048 USA

[9] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA

来源：

GASTROENTEROLOGY | 2023年 / 164卷 / 06期

关键词：

Pancreatic Cancer; Sex; Epidemiology; Incidence; Mortality; POOLED-ANALYSIS; RISK-FACTORS; EARLY-ONSET; COHORT; SEX; LIFE;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

BACKGROUND & AIMS: Previous studies have shown an increasing incidence of pancreatic cancer (PC), especially in younger women; however, this has not been externally validated. In addition, there are limited data about contributing factors to this trend. We report age and sex-specific time-trend analysis of PC age-adjusted incidence rates (aIRs) using the National Program of Cancer Registries database without Surveillance Epidemiology and End Results data. METHODS: PC aIR, mortality rates, annual percentage change, and average annual percentage change (AAPC) were calculated and assessed for parallelism and identicalness. Age-specific analyses were conducted in older (similar to 55 years) and younger (<55 years) adults. PC incidence based on demographics, tumor characteristics, and mortality were evaluated in younger adults. RESULTS: A total of 454,611 patients were diagnosed with PC between 2001 and 2018 with significantly increasing aIR in women (AAPC = 1.27%) and men (AAPC = 1.14%) without a difference (P =.37). Similar results were seen in older adults. However, in younger adults (53,051 cases; 42.9% women), women experienced a greater increase in aIR than men (AAPCs = 2.36%, P <.001 vs 0.62%, P = 0.62) with nonparallel trends (P <.001) and AAPC difference of 1.74% (P <.001). This AAPC difference appears to be due to rising aIR in Blacks (2.23%; P <.001), adenocarcinoma histopathologic subtype (0.89%; P =.003), and location in the headof-pancreas (1.64%; P <.001). PC mortality was found to be unchanged in women but decreasing in counterpart men (AAPC difference = 0.54%; P =.001). CONCLUSION: Using nationwide data, covering z64.5% of the U.S. population, we externally validate a rapidly increasing aIR of PC in younger women. There was a big separation of the incidence trend between women and men aged 15-34 years between 2001 and 2018 (>200% difference), and it did not show slowing down.

引用

页码：978 / +

页数：18

共 43 条

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