From Teeth to Therapy: A Review of Therapeutic Potential within the Secretome of Stem Cells from Human Exfoliated Deciduous Teeth

被引:5
|
作者
Mohd Nor, Nurul Hafizah [1 ]
Mansor, Nur Izzati [2 ]
Kashim, Mohd Izhar Ariff Mohd [1 ,3 ]
Mokhtar, Mohd Helmy [4 ]
Hatta, Farah Ayuni Mohd [1 ]
机构
[1] Univ Kebangsaan Malaysia, Inst Islamic Civilizat, Bangi 43600, Selangor, Malaysia
[2] Univ Kebangsaan Malaysia, Fac Med, Dept Nursing, Kuala Lumpur 56000, Malaysia
[3] Univ Kebangsaan Malaysia, Fac Islamic Studies, Bangi 43600, Selangor, Malaysia
[4] Univ Kebangsaan Malaysia, Fac Med, Dept Physiol, Kuala Lumpur 56000, Malaysia
关键词
secretome; conditioned medium; SHED; dental stem cells; tissue regeneration; MESENCHYMAL STROMAL CELLS; INTERNATIONAL-SOCIETY; CONDITIONED MEDIUM; DIFFERENTIATION; INJURY; RECOVERY; BENEFITS; INFARCT; CULTURE; CORD;
D O I
10.3390/ijms241411763
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Stem cells derived from human exfoliated deciduous teeth (SHED) have emerged as an alternative stem cell source for cell therapy and regenerative medicine because they are readily available, pose fewer ethical concerns, and have low immunogenicity and tumourigenicity. SHED offer a number of advantages over other dental stem cells, including a high proliferation rate with the potential to differentiate into multiple developmental lineages. The therapeutic effects of SHED are mediated by multiple mechanisms, including immunomodulation, angiogenesis, neurogenesis, osteogenesis, and adipogenesis. In recent years, there is ample evidence that the mechanism of action of SHED is mainly due to its paracrine action, releasing a wide range of soluble factors such as cytokines, chemokines, and trophic factors (also known as 'secretome') into the local tissue microenvironment to promote tissue survival and recovery. This review provides an overview of the secretome derived from SHED and highlights the bioactive molecules involved in tissue regeneration and their potential applications in regenerative medicine.
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页数:16
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