Morphologies, mechanical and in vitro behaviors of DLP-based 3D printed HA scaffolds with different structural configurations

被引：11

作者：

Liu, Ke ^{[1
,2
]}

Zhou, Qing ^{[3
]}

Zhang, Xueqin ^{[3
]}

Ma, Lili ^{[1
]}

Xu, Baohua ^{[1
]}

He, Rujie ^{[3
]}

机构：

[1] China Japan Friendship Hosp, Ctr Stomatol, Beijing 100029, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch Peking Union Med Coll, Beijing 100029, Peoples R China

[3] Beijing Inst Technol, Beijing Key Lab Lightweight Multifunct Composite M, Beijing 100081, Peoples R China

来源：

RSC ADVANCES | 2023年 / 13卷 / 30期

基金：

中国国家自然科学基金;

关键词：

GROWTH-FACTOR; BONE; DESIGN; BIOMATERIALS; ARCHITECTURE; OSTEOPONTIN; PROTEIN; VEGF;

D O I：

10.1039/d3ra03080f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the field of bone engineering, porous ceramic scaffolds are in great demand for repairing bone defects. In this study, hydroxyapatite (HA) ceramic scaffolds with three different structural configurations, including the body-centered cubic (BCC), the face-centered cubic (FCC), and the triply periodic minimal surface (TPMS), were fabricated through digital light processing (DLP) based 3D printing technologies. The effects of the structural configurations on the morphologies and mechanical properties of the DLP-based 3D printed HA scaffolds were characterized. Furthermore, in vitro evaluations, including in vitro cytocompatibility, bone alkaline phosphatase (ALP) activity assay, and protein expression, were conducted to assess HA scaffold behavior. Finally, we evaluated the effects of structural configurations from these aspects and selected the most suitable structure of HA scaffold for bone repair.

引用

页码：20830 / 20838

页数：9

共 60 条

[1] Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone
Alcantara, Marice B.
Nemazannikova, Natalie
Elahy, Mina
Dass, Crispin R.
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2014, 66 (11) : 1586 - 1592
[2] Integrally Cored Ceramic Mold Fabricated by Ceramic Stereolithography
Bae, Chang-Jun
Halloran, John W.
[J]. INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 2011, 8 (06) : 1255 - 1262
[3] Bioactive glass and glass-ceramic orbital implants
Baino, Francesco
Verne, Enrica
Fiume, Elisa
Peitl, Oscar
Zanotto, Edgar D.
Brandao, Simone M.
Schellini, Silvana A.
[J]. INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 2019, 16 (05) : 1850 - 1863
[4] Processing methods for making porous bioactive glass-based scaffolds-A state-of-the-art review
Baino, Francesco
Fiume, Elisa
Barberi, Jacopo
Kargozar, Saeid
Marchi, Juliana
Massera, Jonathan
Verne, Enrica
[J]. INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 2019, 16 (05) : 1762 - 1796
[5] Additively manufactured metallic porous biomaterials based on minimal surfaces: A unique combination of topological, mechanical, and mass transport properties
Bobbert, F. S. L.
Lietaert, K.
Eftekhari, A. A.
Pouran, B.
Ahmadi, S. M.
Weinans, H.
Zadpoor, A. A.
[J]. ACTA BIOMATERIALIA, 2017, 53 : 572 - 584
[6] Bogala Mallikharjuna Reddy, 2022, Bioprinting, V28, pe00244, DOI 10.1016/j.bprint.2022.e00244
[7] Understanding of dopant-induced osteogenesis and angiogenesis in calcium phosphate ceramics
Bose, Susmita
Fielding, Gary
Tarafder, Solaiman
Bandyopadhyay, Amit
[J]. TRENDS IN BIOTECHNOLOGY, 2013, 31 (10) : 594 - 605
[8] Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review
Bose, Susmita
Tarafder, Solaiman
[J]. ACTA BIOMATERIALIA, 2012, 8 (04) : 1401 - 1421
[9] ROLE AND REGULATION OF RUNX2 IN OSTEOGENESIS
Bruderer, M.
Richards, R. G.
Alini, M.
Stoddart, M. J.
[J]. EUROPEAN CELLS & MATERIALS, 2014, 28 : 269 - 286
[10] The effect of porosity on the mechanical properties of 3D-printed triply periodic minimal surface (TPMS) bioscaffold
Cai, Zizhen
Liu, Zehua
Hu, Xiaodong
Kuang, Hekun
Zhai, Jinsong
[J]. BIO-DESIGN AND MANUFACTURING, 2019, 2 (04) : 242 - 255

← 1 2 3 4 5 6 →