Concurrent chronic lymphocytic leukemia and primary hyperparathyroidism in a mule

被引：0

作者：

Townsend, Kile S. ^{[1
,2
]}

Johnson, Philip J. ^{[1
,2
,4
]}

Donnelly, Lindsay L. ^{[1
,2
]}

LaCarrubba, Alison M. ^{[1
,2
]}

Lattimer, James C. ^{[1
,2
]}

Havis, Brett ^{[1
,2
]}

Springer, Nora L. ^{[3
]}

Kim, Dae Y. ^{[1
,2
]}

机构：

[1] Univ Missouri, Coll Vet Med, Dept Vet Med, Columbia, MO USA

[2] Univ Missouri, Coll Vet Med, Vet Med Diagnost Lab, Columbia, MO USA

[3] Univ Tennessee, Dept Biomed & Diagnost Sci, Knoxville, TN USA

[4] 900 East Campus Dr, Columbia, MO 65211 USA

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 2023年 / 37卷 / 03期

关键词：

endocrinopathy; equine; hypercalcemia; immunohistochemistry; neoplasia; WORLD-HEALTH-ORGANIZATION; PARATHYROID-HORMONE; HORSE; HYPERCALCEMIA; CLASSIFICATION; LYMPHOMA; SCINTIGRAPHY; DOGS;

D O I：

10.1111/jvim.16714

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A 26-year-old mule gelding was evaluated for chronic weight loss and decreased appetite. The mule had been losing weight and intermittently hypophagic for approximately 7 months. Laboratory analysis of whole blood and plasma identified severe total hypercalcemia, marked hypophosphatemia, markedly increased parathyroid hormone concentration, and marked lymphocytosis. A sestimibi scan intended to identify parathyroid gland tissue was nondiagnostic. Results of flow cytometry and PCR for antigen receptor rearrangement (PARR) were consistent with a B cell lymphoproliferative disorder, likely chronic lymphocytic leukemia (CLL). Although not previously described concurrently, these conditions may sometimes arise together, complicating definition of the underlying mechanism for weight loss and hypercalcemia in aged equids.

引用

页码：1250 / 1255

页数：6

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