Nitration of Pyrrolo[2,1-a]isoquinolines

被引：10

作者：

Chen, Xiao-Hui ^{[1
]}

Ma, Dan-Dan ^{[1
,2
]}

Gao, Xin ^{[1
]}

Li, Yun-Meng ^{[1
]}

Jiang, Da-Bo ^{[1
]}

Ma, Chao ^{[2
]}

Cui, Hai-Lei ^{[1
]}

机构：

[1] Chongqing Univ Arts & Sci, Chongqing 402160, Peoples R China

[2] Hubei Univ, Coll Chem & Chem Engn, Wuhan 430062, Hubei, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 07期

基金：

中国国家自然科学基金;

关键词：

C-H NITRATION; CERIUM(IV) AMMONIUM-NITRATE; BOND NITRATION; FUNCTIONALIZATION; ALKALOIDS; 8-AMINOQUINOLINES; LAMELLARINS; CONVERSION; INDOLINES; EFFICIENT;

D O I：

10.1021/acs.joc.3c00125

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have successfully modified a series of pyrrolo[2,1-a]isoquinolines via direct nitration under mild reaction conditions. Easily accessible nitrates including CAN, Cu(NO3)2 center dot H2O, and Fe(NO3)3 center dot 9H2O all can serve as effective nitrating reagents for functionalizing pyrrolo[2,1-a]isoquinolines. Various nitro-bearing pyrrolo[2,1-a]isoquinolines have been efficiently prepared in acceptable to good yields.

引用

页码：4649 / 4661

页数：13

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