Role of the Gut Microbiota in Children with Kidney Disease

被引：17

作者：

Tain, You-Lin ^{[1
,2
,3
]}

Hsu, Chien-Ning ^{[4
,5
]}

机构：

[1] Kaohsiung Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung 833, Taiwan

[2] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan

[3] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan

[4] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan

[5] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan

来源：

CHILDREN-BASEL | 2023年 / 10卷 / 02期

关键词：

chronic kidney disease; uremic toxin; gut microbiota; short-chain fatty acid; children; trimethylamine N-oxide; tryptophan; BOUND UREMIC TOXINS; INTESTINAL MICROBIOTA; INFLAMMATION; PROBIOTICS; SEVERITY; AST-120; HEALTH; INJURY; RISK; DIET;

D O I：

10.3390/children10020269

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Disruption of the composition and structure of the gut microbiota, namely dysbiosis, dictates the pathophysiology of kidney diseases. The bidirectional kidney-gut axis is of interest in chronic kidney disease (CKD); the uremic milieu leads to intestinal dysbiosis and gut microbial metabolites and toxins implicated in the loss of kidney function and increased comorbidity burden. Considering that kidney diseases can originate in childhood or even earlier in fetal life, identification of the pathogenetic connection between gut microbiota dysbiosis and the development of pediatric renal diseases deserves more attention. This review concentrates on the pathogenic link between dysbiotic gut microbiota and pediatric renal diseases, covering CKD, kidney transplantation, hemodialysis and peritoneal dialysis, and idiopathic nephrotic syndrome. Gut microbiota-targeted therapies including dietary intervention, probiotics, prebiotics, postbiotics and fecal microbial transplantation are discussed for their potential for the treatment of pediatric renal diseases. A deeper understanding of gut microbiota in pediatric renal diseases will aid in developing innovative gut microbiota-targeted interventions for preventing or attenuating the global burden of kidney diseases.

引用

页数：14

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