Combined Loco-Regional and Systemic Treatment Strategies for Hepatocellular Carcinoma: From Basics to New Developments

被引：3
作者：
Della Corte, Angelo [1 ,2 ,3 ]
Rimini, Margherita [4 ]
Steidler, Stephanie [1 ]
Palumbo, Diego [1 ,2 ,3 ]
Ratti, Francesca [5 ]
Aldrighetti, Luca [3 ,5 ]
Cascinu, Stefano [3 ,4 ]
Casadei-Gardini, Andrea [4 ]
De Cobelli, Francesco [1 ,2 ,3 ]
机构：
[1] IRCCS San Raffaele Hosp, Dept Radiol, Via Olgettina 60, I-20132 Milan, Italy
[2] IRCCS San Raffaele Sci Inst, Expt Imaging Ctr, I-20132 Milan, Italy
[3] Univ Vita Salute San Raffaele, I-20132 Milan, Italy
[4] IRCCS San Raffaele Sci Inst, Unit Oncol, I-20132 Milan, Italy
[5] IRCCS San Raffaele Hosp, Hepatobiliary Surg Div, I-20132 Milan, Italy
来源：
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY | 2023年 / 46卷 / 02期
关键词：
Hepatocellular carcinoma; Thermal ablation; Chemoembolization; Radioembolization; Immunotherapy; Tyrosine kinase inhibitors; Combination therapy; COLORECTAL LIVER METASTASES; T-CELL RESPONSES; TRANSARTERIAL CHEMOEMBOLIZATION; RADIOFREQUENCY ABLATION; DOUBLE-BLIND; ARTERIAL CHEMOEMBOLIZATION; PHASE-III; COMBINATION; SORAFENIB; TACE;
D O I：
10.1007/s00270-022-03327-4
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent advances in systemic therapeutic options have led to improved survival in patients with advanced hepatocellular carcinoma. In order to optimize patient outcomes across different disease stages, attempts are being made at exploiting combinations of loco-regional treatments and systemic therapeutic regimens. The possibilities of a beneficial synergistic effect are strongly supported by biological evidence of changes in tumor microenvironment and systemic immunity. With the advent of newer interventional technologies and newer biological and immunological drugs, these possibilities keep on gaining interest and expectations, yet many questions remain unanswered as to how to best manipulate and combine the two therapeutic approaches. This review aims at providing a general overview of biological foundations, preliminary clinical applications, critical issues and future directions of this constantly growing field.
引用
收藏
页码：175 / 186
页数：12
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