A nonadride derivative from the marine-derived fungus Aspergillus chevalieri PSU-AMF79

被引：7
|
作者：
Ningsih, Baiq Nila Sari [1 ,2 ]
Rukachaisirikul, Vatcharin [1 ,2 ]
Phongpaichit, Souwalak [3 ]
Preedanon, Sita [4 ]
Sakayaroj, Jariya [5 ]
Muanprasat, Chatchai [6 ]
机构：
[1] Prince Songkla Univ, Fac Sci, Div Phys Sci, Hat Yai, Songkhla, Thailand
[2] Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai, Songkhla, Thailand
[3] Prince Songkla Univ, Fac Sci, Div Biol Sci, Hat Yai, Songkhla, Thailand
[4] Natl Sci & Technol Dev Agcy NSTDA, Natl Biobank Thailand NBT, Pathum Thani, Thailand
[5] Walailak Univ, Sch Sci, Nakhonsithammarat, Thailand
[6] Mahidol Univ, Ramathibodi Hosp, Chakri Naruebodindra Med Inst, Fac Med, Samut Prakarn, Thailand
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 14期
关键词：
Aspergillus chevalieri; marine-derived fungus; nonadride; dioxopiperazine; enantiomer; antimicrobial activity; TMEM16A inhibitory activity; SECTION ASPERGILLUS; METABOLITE; ANHYDRIDE;
D O I：
10.1080/14786419.2022.2039651
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
One new nonadride enantiomer, ent-epiheveadride, along with five known dioxopiperazine derivatives were isolated from the marine-derived fungus Aspergillus chevalieri PSU-AMF79. Their structures were identified by extensive spectroscopic analysis. The absolute configuration of ent-epiheveadride was determined by comparison of the specific rotation and electronic circular dichroism data with those of related known compounds. It exhibited antifungal activity against Cryptococcus neoformans ATCC90113 flucytosine-resistant and Candida albicans NCPF3153 with the MIC values of 128 and 200 mu g/mL, respectively. In addition, the known L-alanyl-L-tryptophan anhydride displayed TMEM16A inhibitory activity with 65.0% inhibition at a concentration of 5 mu g/mL.
引用
收藏
页码：2311 / 2318
页数：8
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