The Hallmarks of Precancer

被引：5

作者：

Stangis, Mary M. ^{[1
,2
,3
]}

Chen, Zhengyi ^{[4
,5
]}

Min, Jimin ^{[6
,7
]}

Glass, Sarah E. ^{[5
,8
]}

Jackson, Jordan O. ^{[9
,10
]}

Radyk, Megan D. ^{[11
]}

Hoi, Xen Ping ^{[12
,13
]}

Brennen, W. Nathaniel ^{[14
,15
,16
]}

Yu, Ming ^{[10
,17
,18
]}

Dinh, Huy Q. ^{[1
,19
]}

Coffey, Robert J. ^{[5
,8
,20
,21
]}

Shrubsole, Martha J. ^{[21
,22
]}

Chan, Keith S. ^{[12
,13
]}

Grady, William M. ^{[10
,17
,18
]}

Yegnasubramanian, Srinivasan ^{[14
,23
,24
,25
]}

Lyssiotis, Costas A. ^{[11
,26
,27
]}

Maitra, Anirban ^{[6
,7
]}

Halberg, Richard B. ^{[1
,2
,3
]}

Dey, Neelendu ^{[10
,17
,29
]}

Lau, Ken S. ^{[4
,5
,8
,21
,28
,30
]}

机构：

[1] Univ Wisconsin Madison, Dept Oncol, McArdle Lab Canc Res, Madison, WI USA

[2] Univ Wisconsin Madison, Dept Med, Gastroenterol Div, Madison, WI USA

[3] Univ Wisconsin Madison, Carbone Canc Ctr, Madison, WI USA

[4] Vanderbilt Univ, Sch Med, Chem & Phys Biol Program, Nashville, TN USA

[5] Vanderbilt Univ, Med Ctr, Epithelial Biol Ctr, Nashville, TN USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX USA

[7] Univ Texas MD Anderson Canc Ctr, Sheikh Ahmed Ctr Pancreat Canc Res, Houston, TX USA

[8] Vanderbilt Univ, Sch Med, Dept Cell & Dev Biol, Nashville, TN USA

[9] Univ Washington, Dept Lab Med & Pathol, Seattle, WA USA

[10] Fred Hutchinson Canc Ctr, Translat Sci & Therapeut Div, Seattle, WA USA

[11] Univ Michigan, Dept Mol & Integrat Physiol, Med Sch, Ann Arbor, MI USA

[12] Houston Methodist Res Inst, Dept Urol, Houston, TX USA

[13] Houston Methodist Res Inst, Neal Canc Ctr, Houston, TX USA

[14] Johns Hopkins Med, Dept Oncol, Genitourinary Canc Dis Div, Baltimore, MD USA

[15] Johns Hopkins Med, Dept Pharmacol & Mol Sci, Baltimore, MD USA

[16] Johns Hopkins Med, Dept Urol, Baltimore, MD USA

[17] Univ Washington, Dept Med, Div Gastroenterol, Seattle, WA USA

[18] Fred Hutchinson Canc Ctr, Publ Hlth Sci Div, Seattle, WA 98109 USA

[19] Univ Wisconsin Madison, Dept Biostat & Med Informat, Madison, WI USA

[20] Vanderbilt Univ, Med Ctr, Dept Med, Div Gastroenterol Hepatol & Nutr, Nashville, TN USA

[21] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[22] Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA

[23] Johns Hopkins Med, Mol Radiat Sci Div, Radiat Oncol & Mol Radiat Sci, Baltimore, MD USA

[24] Johns Hopkins Med, Dept Pathol, Kidney Urol Pathol Div, Baltimore, MD USA

[25] Johns Hopkins Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[26] Univ Washington, Div Gastroenterol, Internal Med, Seattle, WA USA

[27] Univ Michigan, Med Sch, Rogel Canc Ctr, Ann Arbor, MI USA

[28] Vanderbilt Univ, Med Ctr, Dept Orthoped Surg, Nashville, TN USA

[29] Fred Hutchinson Canc Ctr, 1100 Fairview Ave N, Mail Stop D4-190, Seattle, WA 98109 USA

[30] Vanderbilt Univ, Sch Med, Med Res Bldg IV, 10405A, 2215 Garland Ave, Nashville, TN 37232 USA

来源：

CANCER DISCOVERY | 2024年 / 14卷 / 04期

关键词：

CANCER PREVENTION; BETA-CAROTENE; LUNG-CANCER; REVEALS; TISSUES; CELLS; RISK;

D O I：

10.1158/2159-8290.CD-23-1550

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to prevent overtreatment, an emphasis on the role of genetic and epigenetic aging when considering risk, and the importance of integrating macroenvironmental risk factors with molecules and cells in lesions and at-risk normal tissues for developing effective intervention and health policy strategies.

引用

页码：683 / 689

页数：7

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