How do patient-reported outcome measures affect treatment intensification and patient satisfaction in the management of psoriatic arthritis? A cross sectional study of 503 patients

被引：2

作者：

Coyle, Conor ^{[1
,37
]}

Watson, Lily ^{[2
]}

Whately-Smith, Caroline ^{[3
]}

Brooke, Mel ^{[4
]}

Kiltz, Uta ^{[5
,6
]}

Lubrano, Ennio ^{[7
]}

Queiro, Ruben ^{[8
,9
]}

Trigos, David ^{[10
]}

Brandt-Juergens, Jan ^{[11
]}

Choy, Ernest ^{[12
]}

D'Angelo, Salvatore ^{[13
]}

Delle Sedie, Andrea ^{[14
]}

Dernis, Emmanuelle ^{[15
]}

Wirth, Theo ^{[16
]}

Guis, Sandrine ^{[17
]}

Helliwell, Philip ^{[18
]}

Ho, Pauline ^{[19
]}

Hueber, Axel ^{[20
]}

Joven, Beatriz ^{[21
,22
]}

Koehm, Michaela ^{[23
]}

Morales, Carlos Montilla ^{[24
]}

Packham, Jon ^{[25
]}

Pinto Tasende, Jose Antonio ^{[26
]}

Ramirez, Julio ^{[27
]}

Ruyssen-Witrand, Adeline ^{[28
,29
]}

Scrivo, Rossana ^{[30
]}

Twigg, Sarah ^{[31
]}

Welcker, Martin ^{[32
]}

Soubrier, Martin ^{[33
]}

Gossec, Laure ^{[34
,35
]}

Coates, Laura C. ^{[36
]}

机构：

[1] Univ Oxford, Oxford Univ Hosp, John Radcliffe Hosp, Oxford, England

[2] Univ Bristol, Dept Cellular & Mol Med, Bristol, England

[3] Whately Smith Ltd, Kings Langley, Herts, England

[4] Royal United Hosp, Royal Natl Hosp Rheumat Dis, Bath, England

[5] Ruhr Univ Bochum, Bochum, Germany

[6] Rheumazentrum Ruhrgebiet, Bochum, Germany

[7] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, Acad Rheumatol Unit, Campobasso, Italy

[8] Univ Oviedo, Rheumatol & ISPA Translat Immunol Div, Fac Med, Rheumatol Serv, Oviedo, Spain

[9] Univ Oviedo, Principal Asturias Inst Hlth Res ISPA, Oviedo, Spain

[10] Acc Psoriasis, Barcelona, Spain

[11] Rheumatol Schwerpunktpraxis, Berlin, Germany

[12] Cardiff Univ, Div Infect & Immun, CREATE Ctr, Cardiff, Wales

[13] San Carlo Hosp, Rheumatol Dept Lucania, Potenza, Italy

[14] Azienda Osped Univ Pisana, Rheumatol Unit, Pisa, Italy

[15] Ctr Hosp Mans, Rheumatol Dept, Le Mans, France

[16] Aix Marseille Univ, Rheumatol Dept, INSERM UMRs1097 Autoimmune Arthrit, Marseille, France

[17] Aix Marseille Univ, Rheumatol Dept, Arthrit Autoimmunes, Marseille, France

[18] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England

[19] Manchester Univ NHS Fdn Trust, Kellgren Ctr Rheumatol, Manchester, England

[20] Paracelsus Med Univ, Div Rheumatol, Klinikum Nurnberg, Nurnberg, Germany

[21] Hosp Univ 12 Octubre, Rheumatol Dept, Madrid, Spain

[22] Univ Complutense Madrid, Avda Córdoba sin, Madrid, Spain

[23] Universitiy Hosp Frankfurt, Fraunhofer Inst Translat Med & Cluster Excellence, Rheumatol, Frankfurt, Germany

[24] Hosp Univ Salamanca, Rheumatol Dept, Salamanca, Spain

[25] Univ Nottingham, Acad Unit Populat & Lifespan Sci, Nottingham, England

[26] INIBIC CHU A Coruna, Rheumatol Dept, La Coruna, Spain

[27] Hosp Clin Barcelona, Rheumatol Dept, Arthrit Unit, Barcelona, Spain

[28] Toulouse Univ Hosp, Rheumatol Ctr, Inserm CIC 1436, Toulouse, France

[29] Paul Sabatier Univ Toulouse III, Toulouse, France

[30] Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, Rheumatol Unit, Rome, Italy

[31] Bradford Teaching Hosp NHS Fdn Trust, Rheumatol, Bradford, England

[32] MVZ Rheumatol Dr M Welcker GmbH, Planegg, Germany

[33] Gabriel Montpied Teaching Hosp Clermont Ferrand, Rheumatol Dept, Clermont Ferrand, France

[34] Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ, Rheumatol Dept, INSERM, Paris, France

[35] Hop La Pitie Salpetriere, AP HP, Paris, France

[36] Univ Oxford, Nuffield Dept Orthopaed Rheumatol & Musculoskeleta, Oxford, England

[37] Oxford Univ Hosp, John Radcliffe Hosp, Headley Way, Oxford OX3 9DU, England

来源：

RHEUMATOLOGY | 2024年

关键词：

psoriatic arthritis; PsA; quality of life; PsAID; PsAID-12; ASSIST; HAQ; EQ-5D-5L; patient-reported outcomes; DISEASE-ACTIVITY; PERCEIVED EFFICACY; VALIDATION; QUESTIONNAIRE; CRITERIA; IMPACT; INDEX;

D O I：

10.1093/rheumatology/kead679

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives The AsseSSing Impact in pSoriatic Treatment (ASSIST) study investigated prescribing in routine PsA care and whether the patient-reported outcome-PsA Impact of Disease questionnaire (PsAID-12)-impacted treatment. This study also assessed a range of patient and clinician factors and their relationship to PsAID-12 scoring and treatment modification. Methods Patients with PsA were selected across the UK and Europe between July 2021 and March 2022. Patients completed the PsAID questionnaire and the results were shared with their physician. Patient characteristics, disease activity, current treatment methods, treatment strategies, medication changes and patient satisfaction scores were recorded. Results A total of 503 patients were recruited. Some 36.2% had changes made to treatment, and 88.8% of these had treatment escalation. Overall, the mean PsAID-12 score was higher for patients with treatment escalation; increase in PSAID-12 score is associated with increased odds of treatment escalation (odds ratio 1.58; P < 0.0001). However, most clinicians reported that PsAID-12 did not impact their decision to escalate treatment, instead supporting treatment reduction decisions. Physician's assessment of disease activity had the most statistically significant effect on likelihood of treatment escalation (odds ratio 2.68, per 1-point score increase). Escalation was more likely in patients not treated with biologic therapies. Additional factors associated with treatment escalation included: patient characteristics, physician characteristics, disease activity and disease impact. Conclusion This study highlights multiple factors impacting treatment decision-making for individuals with PsA. PsAID-12 scoring correlates with multiple measures of disease severity and odds of treatment escalation. However, most clinicians reported that the PsAID-12 did not influence treatment escalation decisions. Psoriatic Arthritis Impact of Disease (PsAID) scoring could be used to increase confidence in treatment de-escalation.

引用

页码：242 / 251

页数：10

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