Sustained increase of paediatric invasive Streptococcus pyogenes infections dominated by M1UK and diverse emm12 isolates, Portugal, September 2022 to May 2023

被引：43

作者：

Gouveia, Catarina ^{[1
]}

Bajanca-Lavado, Maria Paula ^{[2
]}

Mamede, Rafael ^{[3
]}

Carvalho, Ana Araujo ^{[1
]}

Rodrigues, Fernanda ^{[4
]}

Melo-Cristino, Jose ^{[3
]}

Ramirez, Mario ^{[3
]}

Friaes, Ana ^{[3
]}

机构：

[1] Ctr Hosp Univ Lisboa Cent, Hosp Dona Estefania, Pediat Dept, Infect Dis Unit, Lisbon, Portugal

[2] Inst Nacl Saude Dr Ricardo Jorge, Dept Doencas Infeciosas, Lab Nacl Referencia Infecoes Resp & Agentes Bacte, Lisbon, Portugal

[3] Univ Lisbon, Inst Microbiol, Inst Med Mol, Fac Med, Lisbon, Portugal

[4] Ctr Hosp Univ Coimbra, Hosp Pediat, Coimbra, Portugal

来源：

EUROSURVEILLANCE | 2023年 / 28卷 / 36期

关键词：

D O I：

10.2807/1560-7917.ES.2023.28.36.2300427

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Since autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the domi-nant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79). Genomic sequencing (n = 55) revealed multiple genetic lineages, dominated by the M1UK sublineage (26/55) and more diverse emm12 isolates (12/55).

引用

页数：7

共 20 条

[1] Increase in Pediatric Invasive Group A Streptococcus Infections - Colorado and Minnesota, October-December 2022 [J].

Barnes, Meghan ;

Youngkin, Erin ;

Zipprich, Jennifer ;

Bilski, Kayla ;

Gregory, Christopher J. ;

Dominguez, Samuel R. ;

Mumm, Erica ;

McMahon, Melissa ;

Como-Sabetti, Kathryn ;

Lynfield, Ruth ;

Chochua, Sopio ;

Onukwube, Jennifer ;

Arvay, Melissa ;

Herlihy, Rachel .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2023, 72 (10) :265-267

[2] Increasing incidence and severity of invasive Group A streptococcal disease in Spanish children in 2019-2022 [J].

Cobo-Vazquez, Elvira ;

Aguilera-Alonso, David ;

Carrasco-Colom, Jaime ;

Calvo, Cristina ;

Saavedra-Lozano, Jesus .

LANCET REGIONAL HEALTH-EUROPE, 2023, 27

[3] Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA [J].

Davies, Mark R. R. ;

Keller, Nadia ;

Brouwer, Stephan ;

Jespersen, Magnus G. G. ;

Cork, Amanda J. J. ;

Hayes, Andrew J. ;

Pitt, Miranda E. E. ;

De Oliveira, David M. P. ;

Harbison-Price, Nichaela ;

Bertolla, Olivia M. M. ;

Mediati, Daniel G. G. ;

Curren, Bodie F. F. ;

Taiaroa, George ;

Lacey, Jake A. A. ;

Smith, Helen V. V. ;

Fang, Ning-Xia ;

Coin, Lachlan J. M. ;

Stevens, Kerrie ;

Tong, Steven Y. C. ;

Sanderson-Smith, Martina ;

Tree, Jai J. J. ;

Irwin, Adam D. D. ;

Grimwood, Keith ;

Howden, Benjamin P. P. ;

Jennison, Amy V. V. ;

Walker, Mark J. J. .

NATURE COMMUNICATIONS, 2023, 14 (01)

[4] Increase in invasive group A streptococcal (Streptococcus pyogenes) infections (iGAS) in young children in the Netherlands, 2022 [J].

de Gier, Brechje ;

Marchal, Niek ;

de Beer-Schuurman, Ilse ;

te Wierik, Margreet ;

Hooiveld, Mariette ;

de Melker, Hester E. ;

van Sorge, Nina M. .

EUROSURVEILLANCE, 2023, 28 (01) :8-13

[5]

European Centre for Disease Prevention and Control (ECDC), 2022, Increase in invasive group A streptococcal infections among children in Europe, including fatalities

[6]

European Centre for Disease Prevention and Control (ECDC), 2023, Weekly Bulletin. Communicable Disease Threats Report, week 50/2023

[7] Annotated Whole-Genome Multilocus Sequence Typing Schema for Scalable High-Resolution Typing of Streptococcus pyogenes [J].

Friaes, A. ;

Mamede, R. ;

Ferreira, M. ;

Melo-Cristino, J. ;

Ramirez, M. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2022, 60 (06)

[8] Changes in emm types and superantigen gene content of Streptococcus pyogenes causing invasive infections in Portugal [J].

Friaes, A. ;

Melo-Cristino, J. ;

Ramirez, M. ;

Vaz, Teresa ;

Giao, Marilia ;

Ferreira, Rui ;

Fonseca, Ana Buschy ;

Oliveira, Henrique ;

Silva, Ana Cristina ;

Costa, Herminia ;

Pinto, Margarida ;

Chantre, Odete ;

Marques, Joao ;

Peres, Isabel ;

Daniel, Isabel ;

Canas, Ema ;

Ferreira, Teresa ;

Marcelo, Cristina ;

Monteiro, Lurdes ;

Lito, Luis Marques ;

Marques, Teresa ;

Martins, Filomena ;

Pessanha, Maria Ana ;

Goncalves, Elsa ;

Morais, Teresa ;

Lopes, Paulo ;

Felicio, Luisa ;

Lameirao, Angelina ;

Mota Vieira, Ana Paula ;

Tomaz, Margarida ;

Bento, Rosa ;

Ramos, Maria Helena ;

Castro, Ana Paula ;

Fonseca, Fernando ;

Castro, Ana Paula ;

Ribeiro, Graca ;

Tome, Rui ;

Pontes, Celeste ;

Boaventura, Luisa ;

Canhoto, Nuno ;

Afonso, Teresa ;

Pina, Teresa ;

Peres, Helena ;

Fontes, Ilse ;

Martinho, Paulo ;

Domingos, Ana ;

Marrao, Gina ;

Grossinho, Jose ;

Ribeiro, Manuela ;

Faustino, Alberta .

SCIENTIFIC REPORTS, 2019, 9 (1)

[9] Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance [J].

Friaes, Ana ;

Pinto, Francisco R. ;

Silva-Costa, Catarina ;

Ramirez, Mario ;

Melo-Cristino, Jose .

BMC MICROBIOLOGY, 2012, 12

[10] Increase in invasive group A streptococcal infection notifications, England, 2022 [J].

Guy, Rebecca ;

Henderson, Katherine L. ;

Coelho, Juliana ;

Hughes, Helen ;

Mason, Emily L. ;

Gerver, Sarah M. ;

Demirjian, Alicia ;

Watson, Conall ;

Sharp, Ashley ;

Brown, Colin S. ;

Lamagni, Theresa .

EUROSURVEILLANCE, 2023, 28 (01) :14-19

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