The Role of the WGR Domain in the Functions of PARP1 and PARP2

被引：0
作者：
Maluchenko, N. V. [1 ]
Korovina, A. N. [1 ]
Saulina, A. A. [1 ]
Studitsky, V. M. [1 ,2 ]
Feofanov, A. V. [1 ,3 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Biol, Moscow 119234, Russia
[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
MOLECULAR BIOLOGY | 2023年 / 57卷 / 05期
关键词：
PARP1; PARP2; WGR; inhibitors; DNA-DAMAGE; POLY(ADP-RIBOSE) POLYMERASE; ALLOSTERIC REGULATION; ACTIVATION; BREAKS; MAINTENANCE; MECHANISM; BINDING; SITES; CELLS;
D O I：
10.1134/S0026893323050114
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.
引用
收藏
页码：802 / 810
页数：9
相关论文
共 50 条
  • [31] Role of PARP1 regulation in radiation-induced rescue effect
    Pathikonda, Spoorthy
    Cheng, Shuk Han
    Yu, Kwan Ngok
    JOURNAL OF RADIATION RESEARCH, 2020, 61 (03) : 352 - 367
  • [32] Iodinated benzimidazole PARP radiotracer for evaluating PARP1/2 expression in vitro and in vivo
    Anderson, Redmond-Craig
    Makvandi, Mehran
    Xu, Kuiying
    Lieberman, Brian P.
    Zeng, Chenbo
    Pryma, Daniel A.
    Mach, Robert H.
    NUCLEAR MEDICINE AND BIOLOGY, 2016, 43 (12) : 752 - 758
  • [33] Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation
    Wang, Shuai
    Han, Lei
    Han, Jungsoo
    Li, Peng
    Ding, Qing
    Zhang, Qing-Jun
    Liu, Zhi-Ping
    Chen, Chuo
    Yu, Yonghao
    NATURE CHEMICAL BIOLOGY, 2019, 15 (12) : 1223 - +
  • [34] Polymorphisms in poly (ADP-ribose) polymerase-1 (PARP1) promoter and 3′ untranslated region and their association with PARP1 expression in breast cancer patients
    Zhai, Lili
    Li, Shuai
    Li, Huilan
    Zheng, Yi
    Lang, Ronggang
    Fan, Yu
    Gu, Feng
    Guo, Xiaojing
    Zhang, Xinmin
    Fu, Li
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (06): : 7059 - 7071
  • [35] Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy
    Peng, Xiaopeng
    Pan, Wanyi
    Jiang, Feng
    Chen, Weiming
    Qi, Zetao
    Peng, Weijie
    Chen, Jianjun
    PHARMACOLOGICAL RESEARCH, 2022, 186
  • [36] Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function
    Feng, Felix Y.
    De Bono, Johann S.
    Rubin, Mark A.
    Knudsen, Karen E.
    MOLECULAR CELL, 2015, 58 (06) : 925 - 934
  • [37] Uncoupling of the transactivation and transrepression functions of PARP1 protein
    Kotova, Elena
    Jarnik, Michael
    Tulin, Alexei V.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (14) : 6406 - 6411
  • [38] Regulation of PARP1/2 and the tankyrases emerging parallels
    Jessop, Matthew
    Broadway, Benjamin J.
    Miller, Katy
    Guettler, Sebastian
    BIOCHEMICAL JOURNAL, 2024, 481 (17) : 1097 - 1123
  • [39] Mechanisms of Nucleosome Reorganization by PARP1
    Maluchenko, Natalya V.
    Nilov, Dmitry K.
    Pushkarev, Sergey V.
    Kotova, Elena Y.
    Gerasimova, Nadezhda S.
    Kirpichnikov, Mikhail P.
    Langelier, Marie-France
    Pascal, John M.
    Akhtar, Md. Sohail
    Feofanov, Alexey V.
    Studitsky, Vasily M.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (22)
  • [40] Increased PARP1-DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1-DNA trapping is correlated with PARP1 inhibitor's cytotoxicity
    Chen, Hua-Dong
    Chen, Chuan-Huizi
    Wang, Yu-Ting
    Guo, Ne
    Tian, Yu-Nan
    Huan, Xia-Juan
    Song, Shan-Shan
    He, Jin-Xue
    Miao, Ze-Hong
    INTERNATIONAL JOURNAL OF CANCER, 2019, 145 (03) : 714 - 727
12345