The Role of the WGR Domain in the Functions of PARP1 and PARP2

被引：0
|
作者：
Maluchenko, N. V. [1 ]
Korovina, A. N. [1 ]
Saulina, A. A. [1 ]
Studitsky, V. M. [1 ,2 ]
Feofanov, A. V. [1 ,3 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Biol, Moscow 119234, Russia
[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
MOLECULAR BIOLOGY | 2023年 / 57卷 / 05期
关键词：
PARP1; PARP2; WGR; inhibitors; DNA-DAMAGE; POLY(ADP-RIBOSE) POLYMERASE; ALLOSTERIC REGULATION; ACTIVATION; BREAKS; MAINTENANCE; MECHANISM; BINDING; SITES; CELLS;
D O I：
10.1134/S0026893323050114
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.
引用
收藏
页码：802 / 810
页数：9
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