The Role of the WGR Domain in the Functions of PARP1 and PARP2

被引：0
|
作者：
Maluchenko, N. V. [1 ]
Korovina, A. N. [1 ]
Saulina, A. A. [1 ]
Studitsky, V. M. [1 ,2 ]
Feofanov, A. V. [1 ,3 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Biol, Moscow 119234, Russia
[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
MOLECULAR BIOLOGY | 2023年 / 57卷 / 05期
关键词：
PARP1; PARP2; WGR; inhibitors; DNA-DAMAGE; POLY(ADP-RIBOSE) POLYMERASE; ALLOSTERIC REGULATION; ACTIVATION; BREAKS; MAINTENANCE; MECHANISM; BINDING; SITES; CELLS;
D O I：
10.1134/S0026893323050114
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.
引用
收藏
页码：802 / 810
页数：9
相关论文
共 50 条
  • [21] The multifaceted role of PARP1 in RNA biogenesis
    Eleazer, Rebekah
    Fondufe-Mittendorf, Yvonne N.
    WILEY INTERDISCIPLINARY REVIEWS-RNA, 2021, 12 (02)
  • [22] Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2
    Deeksha, Waghela
    Rajakumara, Eerappa
    DNA REPAIR, 2024, 133
  • [23] PARP1 in Carcinomas and PARP1 Inhibitors as Antineoplastic Drugs
    Wang, Luyao
    Liang, Chao
    Li, Fangfei
    Guan, Daogang
    Wu, Xiaoqiu
    Fu, Xuekun
    Lu, Aiping
    Zhang, Ge
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (10)
  • [24] Serine-linked PARP1 auto-modification controls PARP inhibitor response
    Prokhorova, Evgeniia
    Zobel, Florian
    Smith, Rebecca
    Zentout, Siham
    Gibbs-Seymour, Ian
    Schutzenhofer, Kira
    Peters, Alessandra
    Groslambert, Josephine
    Zorzini, Valentina
    Agnew, Thomas
    Brognard, John
    Nielsen, Michael L.
    Ahel, Dragana
    Huet, Sebastien
    Suskiewicz, Marcin J.
    Ahel, Ivan
    NATURE COMMUNICATIONS, 2021, 12 (01)
  • [25] The complex universe of inactive PARP1
    Huang, Doudou
    Su, Ziyi
    Mei, Yanxia
    Shao, Zhengping
    TRENDS IN GENETICS, 2024, 40 (12) : 1074 - 1085
  • [26] Poly(ADP-Ribose) Polymerases PARP1 and PARP2 Modulate Topoisomerase II Beta (TOP2B) Function During Chromatin Condensation in Mouse Spermiogenesis
    Meyer-Ficca, Mirella L.
    Lonchar, Julia D.
    Ihara, Motomasa
    Meistrich, Marvin L.
    Austin, Caroline A.
    Meyer, Ralph G.
    BIOLOGY OF REPRODUCTION, 2011, 84 (05) : 900 - 909
  • [27] XRCC1 mediates PARP1-and PAR-dependent recruitment of PARP2 to DNA damage sites
    Lin, Xiaohui
    Leung, Kay Sze Karina
    Wolfe, Kaitlynn F.
    Call, Nicolas
    Bhandari, Seema Khattri
    Huang, Xiaoyu
    Lee, Brian J.
    Tomkinson, Alan E.
    Zha, Shan
    NUCLEIC ACIDS RESEARCH, 2025, 53 (04)
  • [28] BRCA1, PARP1 and γH2AAX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib
    Faraoni, Isabella
    Compagnone, Mirco
    Lavorgna, Serena
    Angelini, Daniela Francesca
    Cencioni, Maria Teresa
    Piras, Eleonora
    Panetta, Paola
    Ottone, Tiziana
    Dolci, Susanna
    Venditti, Adriano
    Graziani, Grazia
    Lo-Coco, Francesco
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2015, 1852 (03): : 462 - 472
  • [29] Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging
    Mahadevan, Jyothi
    Jha, Asmita
    Rudolph, Johannes
    Bowerman, Samuel
    Narducci, Domenic
    Hansen, Anders S.
    Luger, Karolin
    ISCIENCE, 2023, 26 (01)
  • [30] A Single-Molecule Atomic Force Microscopy Study of PARP1 and PARP2 Recognition of Base Excision Repair DNA Intermediates
    Sukhanova, Maria V.
    Hamon, Loic
    Kutuzov, Mikhail M.
    Joshi, Vandana
    Abrakhi, Sanae
    Dobra, Ioana
    Curmi, Patrick A.
    Pastre, David
    Lavrik, Olga I.
    JOURNAL OF MOLECULAR BIOLOGY, 2019, 431 (15) : 2655 - 2673
12345