The Role of the WGR Domain in the Functions of PARP1 and PARP2

被引：0
|
作者：
Maluchenko, N. V. [1 ]
Korovina, A. N. [1 ]
Saulina, A. A. [1 ]
Studitsky, V. M. [1 ,2 ]
Feofanov, A. V. [1 ,3 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Biol, Moscow 119234, Russia
[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
[3] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
MOLECULAR BIOLOGY | 2023年 / 57卷 / 05期
关键词：
PARP1; PARP2; WGR; inhibitors; DNA-DAMAGE; POLY(ADP-RIBOSE) POLYMERASE; ALLOSTERIC REGULATION; ACTIVATION; BREAKS; MAINTENANCE; MECHANISM; BINDING; SITES; CELLS;
D O I：
10.1134/S0026893323050114
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The PARP1 and PARP2 proteins are members of the poly(ADP-ribose) polymerase family involved in the regulation of DNA repair and replication, RNA processing, ribosome biogenesis, transcription, cell division, and cell death. PARP1 and PARP2 are promising targets for the development of anticancer drugs and can be used in the treatment of cardiovascular, neurodegenerative, and other disorders. The WGR domain has been shown to play a central role in the functioning of PARP1 and PARP2 proteins. This review considers the mechanisms of functioning of WGR domains in the PARP1 and PARP2 proteins, which have several similar and specialized properties. Understanding these processes is of great interest to fundamental science and can contribute to the development of more effective and selective inhibitors of PARP1 and PARP2.
引用
收藏
页码：802 / 810
页数：9
相关论文
共 50 条
  • [1] The Role of the WGR Domain in the Functions of PARP1 and PARP2
    N. V. Maluchenko
    A. N. Korovina
    A. A. Saulina
    V. M. Studitsky
    A. V. Feofanov
    Molecular Biology, 2023, 57 : 802 - 810
  • [2] Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
    Murai, Junko
    Huang, Shar-yin N.
    Das, Benu Brata
    Renaud, Amelie
    Zhang, Yiping
    Doroshow, James H.
    Ji, Jiuping
    Takeda, Shunichi
    Pommier, Yves
    CANCER RESEARCH, 2012, 72 (21) : 5588 - 5599
  • [3] Differential Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
    Pommier, Y.
    Huang, S. H.
    Das, B. B.
    Renaud, A.
    Zhang, Y.
    Takeda, S. H.
    Doroshow, J. H.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : 87 - 87
  • [4] Specific and shared biological functions of PARP2-is PARP2 really a lil' brother of PARP1?
    Szanto, Magdolna
    Yelamos, Jose
    Bai, Peter
    EXPERT REVIEWS IN MOLECULAR MEDICINE, 2024, 26
  • [5] Comparative analysis of PARP1 and PARP2 in base excision repair context
    Kutuzov, M.
    Ilina, E.
    Sukhanova, M.
    Belousova, E.
    Khodyreva, S.
    Lavrik, O.
    FEBS OPEN BIO, 2018, 8 : 389 - 390
  • [6] Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
    Zuo, Hao
    Yang, Dengbao
    Yang, Qiwen
    Tang, Haidong
    Fu, Yang-Xin
    Wan, Yihong
    NATURE COMMUNICATIONS, 2020, 11 (01)
  • [7] Comparative analysis of interaction of PARP1 and PARP2 with apurinic/apyrimidinic DNA
    Kutuzov, M.
    Khodyreva, S.
    Ame, J. -C.
    Sukhanova, M.
    Ilina, E.
    Schreiber, V.
    Lavrik, O.
    FEBS JOURNAL, 2013, 280 : 60 - 60
  • [8] Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
    Kurgina, Tatyana A.
    Moor, Nina A.
    Kutuzov, Mikhail M.
    Naumenko, Konstantin N.
    Ukraintsev, Alexander A.
    Lavrik, Olga, I
    COMMUNICATIONS BIOLOGY, 2021, 4 (01)
  • [9] Dual function of HPF1 in the modulation of PARP1 and PARP2 activities
    Tatyana A. Kurgina
    Nina A. Moor
    Mikhail M. Kutuzov
    Konstantin N. Naumenko
    Alexander A. Ukraintsev
    Olga I. Lavrik
    Communications Biology, 4
  • [10] Differential regulation of breast cancer bone metastasis by PARP1 and PARP2
    Hao Zuo
    Dengbao Yang
    Qiwen Yang
    Haidong Tang
    Yang-Xin Fu
    Yihong Wan
    Nature Communications, 11
12345