GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model

被引：4
|
作者：
Jing, Feng [1 ]
Zou, Qian [2 ]
Pu, Yinshuang [2 ]
机构：
[1] Chongqing Gen Hosp, Dept Pathol, 118 Xingguang Ave,Liangjiang New Area, Chongqing 400014, Peoples R China
[2] Chongqing Key Lab Neurodegenerat Dis, 312 Ongshan First Rd, Chongqing 400013, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2023年 / 812卷
关键词：
Liraglutide; GLP-1; receptor; Interleukin-10; Chronic migraine; Central sensitization; Trigeminal nucleus caudalis; NEUROPATHIC-PAIN; INTERLEUKIN-10; MICROGLIA; BEHAVIOR;
D O I：
10.1016/j.neulet.2023.137397
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Glucagon-like peptide-1 receptor (GLP-1R) has been indicated to involve in chronic pain, however, the mechanism by which GLP-1R alleviates the central sensitization of chronic migraine (CM) remains unclear. Treatment with GLP-1R agonist liraglutide attenuated trigeminal allodynia and suppressed the protein levels of CMassociated molecules in the trigeminal nucleus caudalis (TNC). Further analysis showed that injection of liraglutide stimulated the release of IL-10 in the TNC. Treatment with IL-10 also alleviated pain hyperalgesia. Our findings illustrated that liraglutide might alleviate the central sensitization of CM by stimulating the release of IL10, which reveals a novel mechanism of CM.
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页数：9
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