Novel Essential Oils Blend as a Repellent and Toxic Agent against Disease-Transmitting Mosquitoes

被引:6
作者
Kamaraj, Chinnaperumal [1 ]
Kumar, Rajappan Chandra Satish [1 ]
Al-Ghanim, Khalid A. [2 ]
Nicoletti, Marcello [3 ]
Sathiyamoorthy, V. [4 ]
Sarvesh, Sabarathinam [1 ]
Ragavendran, Chinnasamy [5 ]
Govindarajan, Marimuthu [6 ,7 ]
机构
[1] SRM Inst Sci & Technol, Interdisciplinary Inst Indian Syst Med IIISM, Directorate Res, Kattankulathur 603203, Tamil Nadu, India
[2] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia
[3] Sapienza Univ Rome, Fdn Unam Sapientiam, Dept Environm Biol, I-00185 Rome, Italy
[4] Ayurved Mfg, Kancheepuram 631501, Tamil Nadu, India
[5] Saveetha Inst Med & Tech Sci SIMATS, Saveetha Dent Coll & Hosp, Dept Conservat Dent & Endodont, Chennai 600077, Tamil Nadu, India
[6] Annamalai Univ, Dept Zool, Unit Vector Control Phytochemistry & Nanotechnol, Annamalainagar 608002, Tamil Nadu, India
[7] Govt Coll Women Autonomous, Dept Zool, Unit Nat Prod & Nanotechnol, Kumbakonam 612001, Tamil Nadu, India
关键词
essential oil; mosquitoes; larvicide; repellent; molecular docking; STEPHENSI LISTON DIPTERA; MEDICINAL-PLANT EXTRACTS; ODORANT-BINDING PROTEIN; IXODES-RICINUS ACARI; AEDES-AEGYPTI; LARVICIDAL ACTIVITY; INSECT REPELLENTS; CULEX-TRITAENIORHYNCHUS; MALARIAL VECTOR; LEAF EXTRACT;
D O I
10.3390/toxics11060517
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Bio-insecticidal research has focused on long-term vector control using essential oils (EOs). This study examined the larvicidal, oviposition-deterrent, and repellent properties of five medicinal herb-based EO formulations (EOFs) on mosquitoes that are vectors of dengue, filariasis, and malaria. EOFs were significantly more toxic to the larvae and pupae of Culex quinquefasciatus, Anopheles stephensi, and Aedes aegypti with LC50 = 9.23, 12.85, and 14.46 ppm, as well with 10.22, 11.39, and 12.81 ppm, with oviposition active indexes of -0.84, -0.95, and -0.92, respectively. Oviposition-deterrent repellence was found in 91.39%, 94.83%, and 96.09%. EOs and N, N-Diethyl-3-methylbenzamide (DEET) were prepared at various concentrations for time duration repellent bioassays (6.25-100 ppm). Ae. aegypti, An. stephensi, and Cx. quinquefasciatus were monitored for 300, 270, and 180 min, respectively. At 100 ppm, EOs and DEET had comparable repellence in terms of test durations. EOF's primary components d-limonene (12.9%), 2,6-octadienal, 3,7-dimethyl, (Z) (12.2%), acetic acid, phenylmethyl ester (19.6%), verbenol (7.6%), and benzyl benzoate (17.4%) may be combined to make a mosquito larvicidal and repellant equivalent to synthetic repellent lotions. In the molecular dynamics simulations, limonene (-6.1 kcal/mol) and benzyl benzoate (-7.5 kcal/mol) had a positive chemical association with DEET (-6.3 kcal/mol) and interacted with the OBP binding pocket with high affinity and stability. This research will help local herbal product manufacturers and the cosmetics industry in developing 100% herbal insect repellent products to combat mosquito-borne diseases, including dengue, malaria, and filariasis.
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页数:20
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