Innate Vascular Failure by Application of Neuroleptics, Amphetamine, and Domperidone Rapidly Induced Severe Occlusion/Occlusion-like Syndromes in Rats and Stable Gastric Pentadecapeptide BPC 157 as Therapy

被引：11

作者：

Strbe, Sanja ^{[1
]}

Smoday, Ivan Maria ^{[1
]}

Krezic, Ivan ^{[1
]}

Kalogjera, Luka ^{[1
]}

Vukovic, Vlasta ^{[1
]}

Zizek, Helena ^{[1
]}

Gojkovic, Slaven ^{[1
]}

Vranes, Hrvoje ^{[1
]}

Barisic, Ivan ^{[1
]}

Sikiric, Suncana ^{[2
]}

Tepes, Marijan ^{[1
]}

Oroz, Katarina ^{[1
]}

Brkic, Filip ^{[1
]}

Drinkovic, Martin ^{[1
]}

Oreskovic, Lidija Beketic ^{[1
]}

Popic, Jelena ^{[1
]}

Blagaic, Alenka Boban ^{[1
]}

Skrtic, Anita ^{[2
]}

Staresinic, Mario ^{[1
]}

Seiwerth, Sven ^{[2
]}

Sikiric, Predrag ^{[1
]}

机构：

[1] Univ Zagreb, Sch Med, Dept Pharmacol, Zagreb 10000, Croatia

[2] Univ Zagreb, Sch Med, Dept Pathol, Zagreb 10000, Croatia

来源：

PHARMACEUTICALS | 2023年 / 16卷 / 06期

关键词：

vascular failure; neuroleptics; amphetamine; domperidone; occlusion; occlusion-like syndromes; rats; pentadecapeptide BPC 157; ANTIPSYCHOTIC-DRUGS; QT-INTERVAL; L-NAME; DOPAMINE-RECEPTORS; DUODENAL LESIONS; L-ARGININE; BPC-157; PROLONGATION; HALOPERIDOL; STOMACH;

D O I：

10.3390/ph16060788

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Even before behavioral disturbances, neuroleptics, amphetamine, and domperidone application rapidly emerged severe occlusion/occlusion-like syndrome, shared innate vascular and multiorgan failure in rats, comparable to occlusion/occlusion-like syndrome described with vessel(s) occlusion or similar noxious procedures application. As therapy, i.e., activation of the collateral pathways, "bypassing key" (activated azygos vein pathway, direct blood flow delivery), the stable gastric pentadecapeptide BPC 157 is a novel solution. Recently, BPC 157 therapy particularly counteracted neuroleptic- or L-NAME-induced catalepsy, lithium intoxication, and schizophrenia positive and negative symptoms (amphetamine/methamphetamine/apomorphine/ketamine). In rats with complete calvariectomy, medication (BPC 157 10 & mu;g/kg, 10 ng/kg ip or ig) was given 5 min after distinctive dopamine agents (mg/kg ip) (haloperidol (5), fluphenazine (5), clozapine (10), risperidone (5), olanzapine (10), quetiapine (10), or aripiprazole (10), domperidone (25), amphetamine (10), and combined amphetamine and haloperidol) and assessed at 15 min thereafter. All neuroleptic-, domperidone-, and amphetamine-induced comparable vascular and multiorgan failure severe syndrome was alleviated with BPC 157 therapy as before major vessel(s) occlusion or other similar noxious procedures. Specifically, all severe lesions in the brain (i.e., immediate swelling, hemorrhage), heart (i.e., congestion, arrhythmias), and lung (i.e., congestion, hemorrhage), as well as congestion in the liver, kidney, and gastrointestinal (stomach) tract, were resolved. Intracranial (superior sagittal sinus), portal, and caval hypertension and aortal hypotension were attenuated or eliminated. BPC 157 therapy almost annihilated arterial and venous thrombosis, peripherally and centrally. Thus, rapidly acting Virchow triad circumstances that occur as dopamine central/peripheral antagonists and agonist essential class-points, fully reversed by BPC 157 therapy, might be overwhelming for both neuroleptics and amphetamine.

引用

页数：41

共 106 条

[101] The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats [J].